6370-32-7

Basic information

• Product Name: 4,6-dimethylsalicylic acid
• Synonyms: 4,6-dimethylsalicylic acid;2-hydroxy-4,6-dimethylbenzoic acid;6-Hydroxy-2,4-xylic acid;NSC 109119;2,4-Dimethyl-6-hydroxybenzoic acid
• CAS NO: 6370-32-7
• Molecular Formula: C₉H₁₀O₃
• Molecular Weight: 166.1739
• EINECS: 228-880-3
• Mol File: 6370-32-7.mol

Chemical Properties

• Melting Point: 166 °C
• Boiling Point: 323.7°C at 760 mmHg
• Flash Point: 163.8°C
• Appearance: /
• Density: 1.249g/cm³
• Vapor Pressure: 0.000106mmHg at 25°C
• Refractive Index: 1.587
• PKA: 3.07±0.25(Predicted)
• CAS DataBase Reference: 4,6-dimethylsalicylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4,6-dimethylsalicylic acid(6370-32-7)
• EPA Substance Registry System: 4,6-dimethylsalicylic acid(6370-32-7)

Safety Data

• Hazardous Substances Data: 6370-32-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4,6-Dimethylsalicylic acid is used as an active pharmaceutical ingredient for its anti-inflammatory properties, making it suitable for the treatment of various inflammatory conditions.
Used in Cosmetics Industry:
In the cosmetics industry, 4,6-dimethylsalicylic acid is used as an ingredient for its antioxidant properties, which can help protect the skin from oxidative stress and promote skin health.
Used in Chemical Synthesis:
4,6-Dimethylsalicylic acid is used as a building block for the synthesis of various drugs and agrochemicals, contributing to the development of new and effective chemical compounds.
Used in Dyes and Pigments Production:
4,6-dimethylsalicylic acid is also employed in the production of dyes and pigments, where its chemical structure provides color and stability to the final products.
Used as a Chemical Intermediate:
4,6-Dimethylsalicylic acid serves as a chemical intermediate in organic synthesis, facilitating the creation of a range of organic compounds for various applications.

InChI:InChI=1/C9H10O3/c1-5-3-6(2)8(9(11)12)7(10)4-5/h3-4,10H,1-2H3,(H,11,12)

Upstream product

• 37893-39-3 2-hydroxy-4,6-dimethyl-benzoic acid amide 
• 37621-81-1 sodium 3,5-dimethylphenolate 
• 7722-84-1 dihydrogen peroxide 
• 56396-59-9 2-hydroxy-4, 6-dimethylbenzonitrile 
• 75407-50-0 2-hydroxy-4,6-dimethyl-benzaldehyde-oxime 
• 611-01-8 2,4-dimethyl-benzoic acid 
• 15719-64-9 methylammonium carbonate 
• 124-38-9 carbon dioxide 
• 108-68-9 3,5-Dimethylphenol 
• 861621-79-6 3-acetyl-2,5,7-trimethyl-chromen-4-one 

Downstream Products

• 110382-80-4 2-methoxy-4,6-dimethyl-benzoic acid methyl ester 
• 57705-16-5 methyl 4,6-dimethyl-2-hydroxybenzoate 
• 57705-23-4 4-(2-hydroxy-4,6-dimethyl-benzoyl)-morpholine 
• 57705-17-6 ethyl 3,5-dimethyl-phenol-2-carboxylate 

Relevant articles and documents

Palladium-catalyzed ortho-C-H hydroxylation of benzoic acids

A simple Pd(OAc)2 catalyzed ortho-hydroxylation of benzoic acids using TBHP as the sole oxidant has been explored. This protocol features relatively broad substrate scope and operational simplicity. The compatibility of ortho-substituted substrates is an effective complement to the previous ortho-hydroxylation reaction.

Carboxylation of Phenols with CO2 at Atmospheric Pressure

A convenient and efficient method for the ortho-carboxylation of phenols under atmospheric CO2 pressure has been developed. This method provides an alternative to the previously reported Kolbe-Schmitt method, which requires very high pressures of CO2. The addition of a trisubstituted phenol has proved essential for the successful carboxylation of phenols with CO2 at standard atmospheric pressure, allowing the efficient preparation of a broad variety of salicylic acids.