639468-63-6

Basic information

• Product Name: 4-(3-FLUOROBENZOYL)PIPERIDINE
• Synonyms: 4-(3-FLUOROBENZOYL)PIPERIDINE;(3-Fluorophenyl)-4-piperidinyl-Methanone HCl
• CAS NO: 639468-63-6
• Molecular Formula: C₁₂H₁₄FNO
• Molecular Weight: 207.24
• Mol File: 639468-63-6.mol

Chemical Properties

• Boiling Point: 317.6°C at 760 mmHg
• Flash Point: 145.9°C
• Appearance: /
• Density: 1.128g/cm³
• Vapor Pressure: 0.00038mmHg at 25°C
• Refractive Index: 1.522
• Storage Temp.: 2-8°C
• PKA: 9.67±0.10(Predicted)
• CAS DataBase Reference: 4-(3-FLUOROBENZOYL)PIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3-FLUOROBENZOYL)PIPERIDINE(639468-63-6)
• EPA Substance Registry System: 4-(3-FLUOROBENZOYL)PIPERIDINE(639468-63-6)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 639468-63-6(Hazardous Substances Data)

Usage

Uses

Used in Medicinal Chemistry:
4-(3-Fluorobenzoyl)piperidine is used as a building block for the synthesis of new pharmaceutical compounds, leveraging its structural features to create innovative and effective medications.
Used in Drug Discovery:
In the field of drug discovery, 4-(3-Fluorobenzoyl)piperidine is utilized for its potential pharmacological properties, which may contribute to the development of new therapeutic agents.
Used in Organic Chemistry Research and Development:
4-(3-Fluorobenzoyl)piperidine serves as a compound of interest in organic chemistry, where it is investigated for its chemical properties and potential applications in the synthesis of various organic compounds.

InChI:InChI=1/C12H14FNO/c13-11-3-1-2-10(8-11)12(15)9-4-6-14-7-5-9/h1-3,8-9,14H,4-7H2

Upstream product

• 269741-29-9 4-(3-fluorobenzoyl)piperidine-1-carboxylic acid tert-butyl ester 
• 4395-98-6 4-cyanopiperidine 
• 39546-32-2 4-carboxamidopiperidine 
• 91419-52-2 1-tert-butoxycarbonyl-4-cyanopiperidine 

Downstream Products

• 639468-69-2 (3-fluorophenyl)(piperidin-4-yl)methanol 
• 639468-69-2 (+)-(3-fluorophenyl)(piperidin-4-yl)methanol 
• 639468-69-2 (-)-(3-fluorophenyl)(piperidin-4-yl)methanol 

Relevant articles and documents

Syntheses and Binding Studies of New [(Aryl)(aryloxy)methyl]piperidine Derivatives and Related Compounds as Potential Antidepressant Drugs with High Affinity for Serotonin (5-HT) and Norepinephrine (NE) Transporters

In a wide search program toward new, efficient, and fast-acting antidepressant drugs, we have prepared series of new compounds having an (aryl)(aryloxy)methyl moiety linked directly or through a methylene chain to different substituted and unsubstituted cycles (isoquinoline, piperazine, piperidine, tetrahydropyran, or cyclopentane). These compounds have been evaluated for their affinities for serotonin (5-HT) transporter (SERT) and 5-HT1A and 5-HT2A receptors. Racemic mixtures of 4-[(aryl)(aryloxy)methyl]piperidine derivatives showed much higher affinity values for SERT than fluoxetine and resulted in lack of affinity for 5-HT 1A and 5-HT2A receptors. Some of these racemic mixtures were resolved to their enantiomers and tested for binding to norepinephrine (NE) transporter (NET), dopamine (DA) transporter (DAT), and α2 receptor. Several of these enantiomers [(-)-15b, (-)-15j, (-)-15t, (+)-15u] displayed a dual binding profile with affinities for SERT and NET with K i i = 1.9 and 13.5 nM, respectively), and further pharmacological characterization is in progress for its evaluation as a antidepressant.