The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.
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Paragraph 0912-0913
(2019/05/15)
Cyanoguanidine as a versatile, eco-friendly and inexpensive reagent for the synthesis of 2-aminobenzoxazoles and 2-guanidinobenzoxazoles
An effective, easy-to-handle, safe and inexpensive protocol is reported for the synthesis of 2-aminobenzoxazoles under Lewis acid activation, utilising cyanoguanidine as the cyanating reagent. An optimized procedure for the synthesis of 2-guanidinobenzoxazole and novel derivatives is also described.
The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.
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Page/Page column 149
(2010/11/04)
Approach to the synthesis of (+)-ifforestine. Model studies directed at the tetracyclic framework
In order to design an effective asymmetric synthesis of (+)-ifforestine, model approaches to the construction of the tetracyclic ring system have been investigated. These studies have identified two key synthons, a functionalized isatoic anhydride and a p
Roos, Gregory H. P.,Dastlik, Kim A.
p. 2023 - 2044
(2007/10/03)
Formation of nitrogen-containing heterocycles using di(imidazole-1-yl)methanimine
A mild and efficient synthesis of five- and six-membered nitrogen containing heterocyclic compounds, in which di(imidazole-1-yl)methanimine serves as a one-carbon source, is reported.
Wu, Yong-Qian,Limburg, David C.,Wilkinson, Douglas E.,Hamilton, Gregory S.
p. 191 - 193
(2007/10/03)
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