64037-16-7

Usage

Uses

Used in Pharmaceutical and Agrochemical Development:
5-Nitrobenzoxazole-2-amine is used as a key intermediate in the synthesis of pharmaceuticals and agrochemicals for its potential therapeutic and pesticidal properties.
Used in Antimicrobial Applications:
5-Nitrobenzoxazole-2-amine is used as an antimicrobial agent, leveraging its ability to combat various microorganisms, thereby serving in the development of antibiotics and antifungal agents.
Used in Antitumor Applications:
In the field of oncology, 5-Nitrobenzoxazole-2-amine is used as an antitumor agent, showing promise in the mitigation of tumor growth and potentially contributing to cancer treatment strategies.
Used in Antiviral Applications:
5-Nitrobenzoxazole-2-amine is utilized as an antiviral agent, indicating its potential to inhibit viral replication and activity, which is crucial in developing treatments for viral infections.
Used as a Building Block in Organic Synthesis:
5-Nitrobenzoxazole-2-amine is used as a building block in the synthesis of various bioactive molecules, contributing to the creation of new compounds with potential applications in medicine and other industries.
Used in Fluorescent Probe Development:
Leveraging its fluorescent properties, 5-Nitrobenzoxazole-2-amine is used in the development of fluorescent probes for biological imaging and sensing applications, aiding in the advancement of diagnostic tools and research methodologies.

InChI:InChI=1/C7H5N3O3/c8-7-9-5-3-4(10(11)12)1-2-6(5)13-7/h1-3H,(H2,8,9)

Upstream product

• 39835-09-1 5-nitro-2-hydroxybenzonitrile 
• 97-51-8 5-Nitrosalicylaldehyde 
• 506-68-3 bromocyane 
• 61702-43-0 2-amino-4-nitrophenol sodium salt 
• 89853-14-5 (2-hydroxy-5-nitro-phenyl)-guanidine 
• 99-57-0 2-hydroxy-5-nitroaniline 
• 104619-51-4 di(1H-imidazol-1-yl)methanimine 
• 127099-85-8 N-Cyanoguanidine 

Downstream Products

• 1246472-00-3 C₇H₃BrN₂O₃ 
• 14733-77-8 5-amino-2-benzoxazolinone 
• 64037-26-9 benzooxazole-2,5-diamine 

Relevant academic research and scientific papers

INHIBITORS OF HEPATITIS C VIRUS REPLICATION

The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

Cyanoguanidine as a versatile, eco-friendly and inexpensive reagent for the synthesis of 2-aminobenzoxazoles and 2-guanidinobenzoxazoles

An effective, easy-to-handle, safe and inexpensive protocol is reported for the synthesis of 2-aminobenzoxazoles under Lewis acid activation, utilising cyanoguanidine as the cyanating reagent. An optimized procedure for the synthesis of 2-guanidinobenzoxazole and novel derivatives is also described.

INHIBITORS OF HEPATITIS C VIRUS REPLICATION

The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

Formation of nitrogen-containing heterocycles using di(imidazole-1-yl)methanimine

A mild and efficient synthesis of five- and six-membered nitrogen containing heterocyclic compounds, in which di(imidazole-1-yl)methanimine serves as a one-carbon source, is reported.

Approach to the synthesis of (+)-ifforestine. Model studies directed at the tetracyclic framework

In order to design an effective asymmetric synthesis of (+)-ifforestine, model approaches to the construction of the tetracyclic ring system have been investigated. These studies have identified two key synthons, a functionalized isatoic anhydride and a p