- (AZA)INDAZOLYL-ARYL SULFONAMIDE AND RELATED COMPOUNDS AND THEIR USE IN TREATING MEDICAL CONDITIONS
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The invention provides (aza)indazolyl-aryl sulfonamide and related compounds, pharmaceutical compositions, and their use in the treatment of medical conditions, such as cancer, and in inhibiting GCN2 activity.
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Paragraph 0327; 0405
(2020/10/21)
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- NOVEL ANTIBIOTICS AND METHODS OF USING SAME
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The present invention includes novel 3,6-diazabicyclo[3.1.1]heptane antibiotic compounds and any salts or solvates thereof. The present invention further includes methods of preparing such compounds, and methods of treating bacterial infection in a subjec
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- Compound
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PROBLEM TO BE SOLVED: To provide a difluorobenzyl halide derivative useful as a production intermediate for chemicals etc., such as pharmaceuticals, agrochemicals and liquid crystal materials, and a method for efficiently producing the difluorobenzyl halide derivative.SOLUTION: There is provided a compound expressed by general formula (I) (in the formula, Ris a hydrogen atom, chlorine atom, bromine atom, iodine atom or 1-15C alkyl; A, Aand Aare each independently trans-1,4-cyclohexylene wherein one or more ring-constituting methylene groups may be substituted with an oxygen atom or sulfur atom, or 1,4-phenylene wherein one or more hydrogen atoms on a ring may be substituted with a fluorine atom; Z, Zand Zare each independently a single bond, -CHCH-, -(CH)-, -CHO- or -OCH-; l, m and n are each independently 0 or 1; and Xis a chlorine atom, bromine atom or iodine atom).
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Paragraph 0041; 0042
(2018/08/28)
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- LIQUID-CRYSTALLINE COMPOUND HAVING DIFLUOROMETHYLENEOXY GROUP, LIQUID CRYSTAL COMPOSITION, AND LIQUID CRYSTAL DISPLAY ELEMENT
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To provide a liquid crystal compound satisfying at least one of physical properties such as high stability to light, a high clearing point, a low minimum temperature of a liquid crystal phase, small viscosity, suitable optical anisotropy, large dielectric anisotropy, a large dielectric constant in a minor axis direction, a suitable elastic constant and excellent compatibility; a liquid crystal composition containing the compound; and a liquid crystal display device including the composition. The compound is represented by formula (1). For example, R1 is alkyl having 1 to 15 carbons, ring A1 to ring A4 are 1, 4-cyclohexylene or 1, 4-phenylene, Z1 to Z4 are a single bond, - (CH2)2-, -COO- or -CH2O-, X1 is halogen, -C=N, -CF3 or -OCF3, L1 and L2 are hydrogen or fluorine, Y1 and Y2 are fluorine; a, b, c and d each are 0 or 1, and a sum thereof is 1 or 2.
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Paragraph 0124
(2016/01/11)
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- HETEROCYCLIC ANTIVIRAL COMPOUNDS
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Compounds of formula I, wherein R1, R2, R3, X1, X2 and Ar, are as defined herein or pharmaceutically acceptable salts thereof, inhibit HIV-1 reverse transcriptase and afford a method for prevention and treatment of HIV-1 infections and the treatment of AIDS and/or ARC. The present invention also relates to compositions containing compounds of formula I useful for the prevention and treatment of HIV-1 infections and the treatment of AIDS and/or ARC.
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Page/Page column 26
(2009/07/17)
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- Non-nucleoside reverse transcriptase inhibitors
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The present invention provides for compounds useful for treating an HIV infection, or preventing an HIV infection, or treating AIDS or ARC. The compounds of the invention are of formula I wherein A is A1, A2, A3 or A4 and R1, R2, R3, R4a, R4b, R5, R6, Ar, X1, X2, X4, X4 and X5 are as herein defined. Also disclosed in the present invention are methods of treating an HIV infection with compounds defined herein and pharmaceutical compositions containing said compounds.
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Page/Page column 23-24
(2008/06/13)
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- Non-nucleoside reverse transcriptase inhibitors
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Compounds of formula I, wherein R1, R2, R3, R4, R5, X, Y, and Ar are as defined herein or pharmaceutically acceptable salts thereof, inhibit HIV-1 reverse transcriptase and afford a method for prevention and treatment of HIV-1 infections and the treatment of AIDS and/or ARC. The present invention also relates to compositions containing compounds of formula I useful for the prevention and treatment of HIV-1 infections and the treatment of AIDS and/or ARC.
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Page/Page column 16; 23
(2008/12/08)
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- Heterocyclic antiviral compounds
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The present invention relates to a compounds according to formula I, methods for treating diseases mediated by human immunodeficieny virus by administration of a compound according to formula I and pharmaceutical compositions for treating diseases mediated by human immunodeficieny virus containing a compound according to formula I where R1, R2, R3, R4, R5, are as defined herein.
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Page/Page column 11; 21
(2010/02/15)
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- Heterocyclic reverse transcriptase inhibitors
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The present invention provides compounds for treating or preventing an HIV infection, or treating AIDS or ARC comprising administering a compound according to formula I where R1, R2 and R3, are as defined herein.
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Page/Page column 5; 9
(2010/11/24)
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- Non-nucleoside reverse transcriptase inhibitors
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The present invention provides compounds for treating or preventing an HIV infection, or treating AIDS or ARC comprising administering a compound according to formula I where Ar, R1-R5, R7a, R7b, R7c, R8-R10, X1, X2 m, n, o and p are as defined herein.
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Page/Page column 50
(2008/06/13)
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