644985-24-0

Basic information

• Product Name: 2,3-DIFLUORO-4-BROMOBENZALDEHYDE
• Synonyms: 2,3-DIFLUORO-4-BROMOBENZALDEHYDE ;4-Bromo-2,3-difluorobenzaldehyde 95+%;4-Bromo-2,3-fluorobenzaldehyde
• CAS NO: 644985-24-0
• Molecular Formula: C₇H₃BrF₂O
• Molecular Weight: 220.9989264
• EINECS: 642-799-4
• Mol File: 644985-24-0.mol
• Article Data: 10

Chemical Properties

• Melting Point: 66-67℃
• Boiling Point: 239.859 °C at 760 mmHg
• Flash Point: 98.864 °C
• Appearance: Off-white/Powder
• Density: 1.758 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: 2,3-DIFLUORO-4-BROMOBENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-DIFLUORO-4-BROMOBENZALDEHYDE(644985-24-0)
• EPA Substance Registry System: 2,3-DIFLUORO-4-BROMOBENZALDEHYDE(644985-24-0)

Safety Data

• Hazardous Substances Data: 644985-24-0(Hazardous Substances Data)

Usage

Uses

4-Bromo-2,3-difluorobenzaldehyde is used as pharmaceutical intermediates.

Upstream product

• 867366-94-7 (2,3-difluoro-1,4-phenylene)bis(trimethylsilane) 
• 367-11-3 ortho-difluorobenzene 
• 38573-88-5 1-bromo-2,3-difluorobenzene 
• 68-12-2 N,N-dimethyl-formamide 
• 156682-52-9 1,4-dibromo-2,3-difluoro-benzene 

Downstream Products

• 644985-29-5 3-(4-bromo-2,3-difluoro-phenyl)-2,2-dimethyl-3-oxo-propionic acid methyl ester 
• 644985-34-2 [4-(4,4-dimethyl-5-oxo-4,5-dihydro-1H-pyrazol-3-yl)-2,3-difluoro-phenyl]-carbamic acid benzyl ester 
• 867366-95-8 C₁₄H₆BrClFNO₂ 
• 1068603-93-9 5-(3-bromo-2-fluoro-6-formyl-phenoxy)-N,N'-di-tert-butyl-isophthalamide 
• 910825-41-1 C₁₅H₇BrF₃NO₂ 
• 1427396-09-5 6-bromo-7-fluoro-1H-indazole 

Relevant articles and documents

(AZA)INDAZOLYL-ARYL SULFONAMIDE AND RELATED COMPOUNDS AND THEIR USE IN TREATING MEDICAL CONDITIONS

The invention provides (aza)indazolyl-aryl sulfonamide and related compounds, pharmaceutical compositions, and their use in the treatment of medical conditions, such as cancer, and in inhibiting GCN2 activity.

Compound

PROBLEM TO BE SOLVED: To provide a difluorobenzyl halide derivative useful as a production intermediate for chemicals etc., such as pharmaceuticals, agrochemicals and liquid crystal materials, and a method for efficiently producing the difluorobenzyl halide derivative.SOLUTION: There is provided a compound expressed by general formula (I) (in the formula, Ris a hydrogen atom, chlorine atom, bromine atom, iodine atom or 1-15C alkyl; A, Aand Aare each independently trans-1,4-cyclohexylene wherein one or more ring-constituting methylene groups may be substituted with an oxygen atom or sulfur atom, or 1,4-phenylene wherein one or more hydrogen atoms on a ring may be substituted with a fluorine atom; Z, Zand Zare each independently a single bond, -CHCH-, -(CH)-, -CHO- or -OCH-; l, m and n are each independently 0 or 1; and Xis a chlorine atom, bromine atom or iodine atom).

HETEROCYCLIC ANTIVIRAL COMPOUNDS

Compounds of formula I, wherein R1, R2, R3, X1, X2 and Ar, are as defined herein or pharmaceutically acceptable salts thereof, inhibit HIV-1 reverse transcriptase and afford a method for prevention and treatment of HIV-1 infections and the treatment of AIDS and/or ARC. The present invention also relates to compositions containing compounds of formula I useful for the prevention and treatment of HIV-1 infections and the treatment of AIDS and/or ARC.