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RUBUSOSIDE, a natural sweetener derived from Stevia rebaudiana, is a glycoside known for its high sweetness and low caloric content. It is a promising alternative to traditional sugar, offering a healthier option for those seeking to reduce their sugar intake or manage diabetes.

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  • 64849-39-4 Structure
  • Basic information

    1. Product Name: RUBUSOSIDE
    2. Synonyms: RUBUSOSIDE;13β-(β-D-Glucopyranosyloxy)kaur-16-en-18-oic acid β-D-glucopyranosyl ester;RUBESCENSIN A(RG);(4alpha)-13-(beta-D-Glucopyranosyloxy)kaur-16-en-18-oic acid beta-D-glucopyranosyl ester;(4α)-13-(β-D-glucopyranosyloxy)kaur-16-en-18-oic acid β-D-glucopyranosyl ester;Rubusoside (100 mg);Rubus Suavissmus S. Lee;Rubusoside(P)
    3. CAS NO:64849-39-4
    4. Molecular Formula: C32H50O13
    5. Molecular Weight: 642.73
    6. EINECS: N/A
    7. Product Categories: chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract
    8. Mol File: 64849-39-4.mol
  • Chemical Properties

    1. Melting Point: 178~181℃
    2. Boiling Point: 802.5oC at 760 mmHg
    3. Flash Point: 251.9oC
    4. Appearance: /
    5. Density: 1.45
    6. Vapor Pressure: 8.59E-30mmHg at 25°C
    7. Refractive Index: 1.628
    8. Storage Temp.: Hygroscopic, Refrigerator, under inert atmosphere
    9. Solubility: DMSO (Slightly), Methanol (Slightly, Sonicated), Water (Slightly)
    10. PKA: 12.51±0.70(Predicted)
    11. Stability: Hygroscopic
    12. CAS DataBase Reference: RUBUSOSIDE(CAS DataBase Reference)
    13. NIST Chemistry Reference: RUBUSOSIDE(64849-39-4)
    14. EPA Substance Registry System: RUBUSOSIDE(64849-39-4)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany: 3
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 64849-39-4(Hazardous Substances Data)

64849-39-4 Usage

Uses

Used in Food and Beverage Industry:
RUBUSOSIDE is used as a nutritive sweetener for its ability to provide sweetness without contributing significant calories. This makes it an ideal choice for consumers looking to reduce their sugar consumption or manage their blood sugar levels.
Used in Pharmaceutical Industry:
RUBUSOSIDE is used as an ingredient in various pharmaceutical products, particularly those aimed at diabetes management or weight loss. Its low-calorie profile and natural origin make it a preferred choice for health-conscious consumers.
Used in Health and Wellness Products:
RUBUSOSIDE is also utilized in the development of health and wellness products, such as dietary supplements and nutritional shakes, due to its sweetening properties and minimal impact on blood sugar levels.

Check Digit Verification of cas no

The CAS Registry Mumber 64849-39-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,4,8,4 and 9 respectively; the second part has 2 digits, 3 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 64849-39:
(7*6)+(6*4)+(5*8)+(4*4)+(3*9)+(2*3)+(1*9)=164
164 % 10 = 4
So 64849-39-4 is a valid CAS Registry Number.
InChI:InChI=1/C32H50O13/c1-15-11-31-9-5-18-29(2,7-4-8-30(18,3)28(41)44-26-24(39)22(37)20(35)16(12-33)42-26)19(31)6-10-32(15,14-31)45-27-25(40)23(38)21(36)17(13-34)43-27/h16-27,33-40H,1,4-14H2,2-3H3/t16-,17-,18+,19+,20-,21-,22+,23+,24-,25-,26+,27+,29-,30-,31?,32+/m1/s1

64849-39-4 Well-known Company Product Price

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  • Sigma-Aldrich

  • (62933)  Rubusoside  analytical standard

  • 64849-39-4

  • 62933-10MG

  • 4,442.49CNY

  • Detail

64849-39-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name RUBUSOSIDE

1.2 Other means of identification

Product number -
Other names RUBESCENSIN A(RG)

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:64849-39-4 SDS

64849-39-4Relevant articles and documents

Glucosyltransferase Capable of Catalyzing the Last Step in Neoandrographolide Biosynthesis

Li, Yuan,Lin, Hui-Xin,Wang, Jian,Yang, Jian,Lai, Chang-Jiang-Sheng,Wang, Xing,Ma, Bao-Wei,Tang, Jin-Fu,Li, Yong,Li, Xin-Lin,Guo, Juan,Gao, Wei,Huang, Lu-Qi

supporting information, p. 5999 - 6002 (2018/10/20)

ApUGT, a diterpene glycosyltransferase from Andrographis paniculata, could transfer a glucose to the C-19 hydroxyl moiety of andrograpanin to form neoandrographolide. This glycosyltransferase has a broad substrate scope, and it can glycosylate 26 natural and unnatural compounds of different structural types. This study provides a basis for exploring the glycosylation mechanism of ent-labdane-type diterpenes and plays an important role in diversifying the structures used in drug discovery.

Development of Photoaffinity Probe for the Discovery of Steviol Glycosides Biosynthesis Pathway in Stevia rebuadiana and Rapid Substrate Screening

Li, Weichao,Zhou, Yiqing,You, Wenjing,Yang, Mengquan,Ma, Yanrong,Wang, Mingli,Wang, Yong,Yuan, Shuguang,Xiao, Youli

, p. 1944 - 1949 (2018/06/11)

Functional discovery and characterization of the target enzymes responsible for the biosynthesis pathway coded for the genes is ongoing, and the unknown functional diversity of this class of enzymes has been revealed by genome sequencing. Commonly, it is feasible in annotating of biosynthetic genes of prokaryotes due to the existence of gene clusters of secondary metabolites. However, in eukaryotes, the biosynthetic genes are not compactly clustered in the way of prokaryotes. Hence, it remains challenging to identify the biosynthetic pathways of newly discovered natural products in plants. Steviol glycosides are one class of natural sweeteners found in high abundance in the herb Stevia rebaudiana. Here, we applied the chemoproteomic strategy for the proteomic profiling of the biosynthetic enzymes of steviol glycosides in Stevia rebaudiana. We not only identified a steviol-catalyzing UDP-glycosyltransferase (UGT) UGT73E1 involved in steviol glycoside biosynthesis but also built up a probe-based platform for the screening of potential substrates of functional uncharacterized UGT rapidly. This approach would be a complementary tool in mining novel synthetic parts for assembling of synthetic biological systems for the biosynthesis of other complex natural products.

A complete specific cleavage of glucosyl and ester linkages of stevioside for preparing steviol with a β-galactosidase from Sulfolobus solfataricus

Chen, Jun-Ming,Xia, Yong-Mei,Wan, Hui-Da,Wang, Hai-Jun,Liu, Xiang

, p. 126 - 131 (2014/06/10)

β-Galactosidases from Sulfolobus solfataricus have been used to synthesize galactooligosaccharide and lactulose. In this work, a β-galactosidase from S. solfataricus with weak β-glucosidase activity but high lipase activity was employed as catalyst to assist hydrolysis of stevioside to obtain steviol, an important starting reagent of synthetic bioactive materials and the main metablite of stevioside in human digistion. The β-galactosidase presented a strict substrate specifity on converting stevioside to steviol in a stoichiometric yield. The β-galactosidase favors the cleavage of glycoside linkages prior to cleavage of glycosyl ester linkage. The hydrolysis is external diffusion controlled and hence has to bear low substrate concentration in regular process, but this can be solved with product removal or enzyme immobilization. The immobilization of the β-galactosidase onto cross-linked chitosan microspheres did not enhance the enzyme's thermal or pH stability but eliminated the external diffusion, and therefore speeded the hydrolysis in 3 folds. The relative reaction activity dropped only 1.75% after 6 runs of using the immobilized β-galactosidase.

Solubilization of steviolbioside and steviolmonoside with γ-cyclodextrin and its application to selective syntheses of better sweet glycosides from stevioside and rubusoside

Ohtani,Aikawa,Fujisawa,Kasai,Tanaka,Yamasaki

, p. 3172 - 3174 (2007/10/02)

1,4-α-Glucosylation at the 13-O-glycosyl moiety of stevioside (S) and rubusoside (RU) results in a significant increase of sweetness. Saponification of the 19-COO-β-glucosyl linkage of S and RU yielded steviolbioside (SB) (= 13-O-β-sophorosyl-steviol) and steviolmonoside (SM) (= 13-O-β-glucosyl-steviol), respectively, both of which are poorly soluble in an acetate buffer. It was found that the solubilities of SM and SB in the buffer solution were remarkably increased in the presence of γ-cyclodextrin (γ-CD). SB was solubilized in the buffer solution with the aid of γ-CD, and the solution was subjected to 1,4-α-transglucosylation by using a cyclodextrin glucanotransferase-starch system to give a mixture of products which were glucosylated at the 13-O-glycosyl moiety. This mixture was acetylated, and the acetate was subjected to chemical β-glucosylation of 19-COOH followed by deacetylation to afford compounds which have superior sweetness to S. In the same way, derivatives with superior sweetness were selectively prepared from RU through SM.

BIOTRANSFORMATION OF STEVIOL BY CULTURED CELLS OF EUCALYPTUS PERRINIANA AND COFFEE ARABICA

Orihara, Yutaka,Saiki, Kenji,Furuya, Tsutomu

, p. 3989 - 3992 (2007/10/02)

A new biotransformation product, steviol 19-β-gentiobiosyl ester, together with steviol 19-β-glucopyranosyl ester and steriol-13-O-β-glucopyranosyl ester (rubusoside), was isolated from Eucalyptus perriniana jar fermentor culture following the administration of steviol.Only rubusoside was isolated as a biotransformation product of steviol from Coffea arabica cell suspension culture.Key Word Index: Eucalyptus perriniana; Myrtaceae; Coffee arabica: Rubiaceae; cell suspension culture; biotransformation; steviol; rubusoside; steviol 19-β-gentiobiosyl ester; glucosylation.

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