6521-33-1

Basic information

• Product Name: N-METHYLFURAN-2-CARBOXIMIDOYL CHLORIDE
• Synonyms: 2-FurancarboxiMidoylchloride, N-Methyl-
• CAS NO: 6521-33-1
• Molecular Formula: C6H6ClNO
• Molecular Weight: 143.57
• Mol File: 6521-33-1.mol

Chemical Properties

• Boiling Point: 188.6°C at 760 mmHg
• Flash Point: 67.9°C
• Appearance: /
• Density: 1.19g/cm³
• Vapor Pressure: 0.82mmHg at 25°C
• Refractive Index: 1.52
• CAS DataBase Reference: N-METHYLFURAN-2-CARBOXIMIDOYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-METHYLFURAN-2-CARBOXIMIDOYL CHLORIDE(6521-33-1)
• EPA Substance Registry System: N-METHYLFURAN-2-CARBOXIMIDOYL CHLORIDE(6521-33-1)

Safety Data

• Hazardous Substances Data: 6521-33-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
N-METHYLFURAN-2-CARBOXIMIDOYL CHLORIDE is used as a reagent for the preparation of various pharmaceuticals. Its ability to selectively modify the nitrogen atoms in aromatic compounds makes it a valuable tool in the production of complex organic molecules.
Used in Agrochemical Industry:
N-METHYLFURAN-2-CARBOXIMIDOYL CHLORIDE is used as a reagent in the synthesis of agrochemicals. Its versatility in organic synthesis allows for the development of new and effective compounds for agricultural applications.
Used in Fine Chemicals Industry:
N-METHYLFURAN-2-CARBOXIMIDOYL CHLORIDE is used as a reagent in the production of other fine chemicals. Its unique properties and reactivity contribute to the synthesis of a wide range of specialty chemicals.
Note: When handling N-METHYLFURAN-2-CARBOXIMIDOYL CHLORIDE, care must be taken as it is a powerful lachrymator and can cause irritation to the eyes and respiratory system.

InChI:InChI=1/C6H6ClNO/c1-8-6(7)5-3-2-4-9-5/h2-4H,1H3/b8-6-

Upstream product

• 21402-85-7 N-methylfuran-2-carboxamide 
• 88-14-2 2-furanoic acid 
• 527-69-5 2-furancarbonyl chloride 

Relevant articles and documents

Transition metal-free one-pot synthesis of 2-substituted 3-carboxy-4-quinolone and chromone derivatives

A novel one-pot synthesis of the 2-substituted 3-carboxy-4-quinolone/ chromone derivatives from readily available 3-oxo-3-arylpropanoates and amides/acyl chlorides is reported, without any transition metal aid. The Royal Society of Chemistry 2013.

Synthesis of some novel imidate derivatives of thiophene and furan: Investigations of their metallation properties and some synthetic applications

Methyl N-methyl and methyl N-(2,4,6-trimethyl)phenyl-2-carboximidates of thiophene and furan have been synthesized in excellent yields by the reactions of sodium methoxide in methanol with the corresponding N-methyl- and N-(2,4,6-trimethyl)phenyl-2-carboxymidoyl chlorides, which in turn, were obtained from their respective secondary amides by refluxing in neat thionyl chloride. A thorough investigation into the directed lithiation properties of the these heteroaryl-2-imidates with various lithiating agents, solvents, and reaction conditions revealed almost exclusive C5-lithiation. This regioselectivity is in contrast to the C3-lithiation reported for the oxazolino functionality (a cyclic imidate). The synthetic utility of the C5-lithiated intermediate of methyl N-methyl-thiophene-2-carboximidate with various electrophiles is demonstrated. C3-Lithiation has been effected in the case of methyl N-methylthiophene-2-carboximidate when the C5-position is blocked with a removable trimethylsilyl group. Methyl thiophene-2-carboximidate, an N-unsubstituted imidate, was found to eliminate methoxide ion and undergo subsequent C5-lithiation to give 5-lithiothiophene-2-carbonitrile with LDA. n-Butyllithium gave rise predominantly to products resulting from nucleophilic addition to the nitrile group.