21402-85-7

Basic information

• Product Name: N-methyl-2-furamide
• Synonyms: N-methyl-2-furamide
• CAS NO: 21402-85-7
• Molecular Formula: C₆H₇NO₂
• Molecular Weight: 125.12528
• Mol File: 21402-85-7.mol
• Article Data: 19

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-methyl-2-furamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-methyl-2-furamide(21402-85-7)
• EPA Substance Registry System: N-methyl-2-furamide(21402-85-7)

Safety Data

• Hazardous Substances Data: 21402-85-7(Hazardous Substances Data)

Upstream product

• 88-14-2 2-furanoic acid 
• 593-51-1 methylamine hydrochloride 
• 1121-47-7 2-furaldehyde oxime 
• 67-56-1 methanol 
• 527-69-5 2-furancarbonyl chloride 
• 609-38-1 furan-2-carboxylic acid amide 
• 80-43-3 bis(1-methyl-1-phenylethyl)peroxide 
• 74-89-5 methylamine 
• 95091-92-2 N-methoxy-N-methyl-2-furancarboxamide 
• 74-88-4 methyl iodide 
• 611-13-2 2-furoic acid methyl ester 
• 84738-96-5 C₂H₇AlClN 

Downstream Products

• 4753-75-7 N-methyl-2-furanmethanamine 
• 108902-73-4 dimethyl-(α-phenylsulfanyl-furfuryliden)-ammonium; iodide 
• 6521-33-1 N-methylfuran-2-carboximidoyl chloride 
• 1235479-05-6 6-methyl-4,5-diphenylfuro[2,3-c]pyridin-7(6H)-one 
• 614-99-3 Ethyl 2-furoate 
• 10354-48-0 furan-2-carboxylic acid benzylamide 
• 147973-27-1 Furan-2-carboxylic acid (diphenyl-phosphinoylmethyl)-methyl-amide 

Relevant articles and documents

An unusual approach to spirolactones and related structures

Spirocyclic structures can be obtained by an ipso-type radical cyclisation onto a furan or a suitably substituted pyrrole followed by oxidation of the stabilised radical adduct. The Royal Society of Chemistry 2006.

-

-

Dealkoxylation ofN-alkoxyamides without an external reductant driven by Pd/Al cooperative catalysis

Lewis acid-assisted palladium-catalysed dealkoxylation ofN-alkoxyamides has been developed. This reaction proceeded smoothly with a range ofN-alkoxyamides in the absence of an external reductant, thereby establishing a convenient and reductant-free protocol. In addition, a gram-scale reaction could be achieved. Preliminary mechanistic investigations indicated that β-hydrogen elimination from a palladium alkoxide intermediate generated an intramolecular hydride source.

Tandem Transformation of Aldoximes to N-Methylated Amides Using Methanol

Tandem conversion of aldoximes to N-methylated amides with methanol in presence of a single Ru(II) catalyst is accomplished through the Ru(II)-mediated rearrangement followed by the reductive N-methylation. Employing this protocol, several aldoximes were directly transformed to the N-methylated amides using methanol. Kinetic experiments with H218O advocated that the aldoxime is acted as the nucleophile during the aldoxime to amide rearrangement process. Involvement of nitrile intermediate during this transformation is realized from the kinetic study. (Figure presented.).