65224-66-0

Basic information

• Product Name: 2-CHLORO-6-METHYL-5-NITRO-4(1H)-PYRIMIDINONE
• Synonyms: 2-CHLORO-6-METHYL-5-NITROPYRIMIDIN-4-OL;2-CHLORO-6-METHYL-5-NITROURACIL;2-CHLORO-6-METHYL-5-NITRO-4(1H)-PYRIMIDINONE;2-Chloro-6-methylnitro-4(1H)-pyrimidinone;2-chloro-6-methyl-5-nitro-3H-pyrimidin-4-one;6-chloro-2-Methyl-5-nitropyriMidin-4-ol;2-chloro-6-Methyl-1-nitro-1,4-dihydropyriMidin-4-one;2-Chloro-4-hydroxy-6-methyl-5-nitropyrimidine
• CAS NO: 65224-66-0
• Molecular Formula: C₅H₄ClN₃O₃
• Molecular Weight: 189.56
• Mol File: 65224-66-0.mol

Chemical Properties

• Boiling Point: 276℃
• Flash Point: 121℃
• Appearance: Gray/Solid
• Density: 1.80
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.628
• CAS DataBase Reference: 2-CHLORO-6-METHYL-5-NITRO-4(1H)-PYRIMIDINONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-6-METHYL-5-NITRO-4(1H)-PYRIMIDINONE(65224-66-0)
• EPA Substance Registry System: 2-CHLORO-6-METHYL-5-NITRO-4(1H)-PYRIMIDINONE(65224-66-0)

Safety Data

• Hazardous Substances Data: 65224-66-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
2-CHLORO-6-METHYL-5-NITRO-4(1H)-PYRIMIDINONE is used as a key intermediate in the development of pharmaceuticals for its ability to be incorporated into the molecular structures of various drugs. Its unique functional groups facilitate the formation of new chemical entities with potential therapeutic applications.
Used in Agrochemical Production:
In the agrochemical industry, 2-CHLORO-6-METHYL-5-NITRO-4(1H)-PYRIMIDINONE serves as a building block for the synthesis of pesticides and other crop protection agents. Its chemical properties allow for the creation of compounds that can effectively target and control pests and diseases in agriculture.
Used in Organic Synthesis as an Intermediate:
2-CHLORO-6-METHYL-5-NITRO-4(1H)-PYRIMIDINONE is utilized as an intermediate in organic synthesis, where it can undergo further reactions to produce a range of derivative compounds. Its reactivity and functional groups make it a valuable component in the synthesis of complex organic molecules for various applications, including specialty chemicals and advanced materials.

InChI:InChI=1/C5H4ClN3O3/c1-2-3(9(11)12)4(10)8-5(6)7-2/h1H3,(H,7,8,10)

Upstream product

• 13162-26-0 2,4-dichloro-6-methyl-5-nitropyrimidine 
• 16632-21-6 6-methyl-5-nitropyrimidine-2,4-diol 

Downstream Products

• 13162-24-8 2-amino-4-chloro-5-nitro-6-methylpyrimidine 
• 937365-20-3 C₁₃H₁₃ClN₄O₂ 
• 937365-36-1 C₁₂H₉Cl₃N₄O₂ 
• 937365-35-0 C₁₂H₉Cl₃N₄O₂ 
• 937365-34-9 C₁₂H₉ClF₂N₄O₂ 
• 937365-33-8 C₁₃H₉ClF₄N₄O₂ 
• 937365-32-7 C₁₂H₉Cl₂FN₄O₂ 
• 937365-31-6 C₁₂H₉ClF₂N₄O₂ 

Relevant articles and documents

SAR studies on a novel series of human cytomegalovirus primase inhibitors

A novel series of imidazolylpyrimidines were found to possess inhibitory activity against the human CMV UL70 primase. Extensive SAR studies on an HTS lead led to potent, orally bioavailable compounds with anti-CMV IC50 values of 150 nM in both

Discovery of a novel series of inhibitors of human cytomegalovirus primase

Infection by human cytomegalovirus (hCMV) remains a potent threat to susceptible people throughout the world. We have discovered a series of imidazolyl-pyrimidine compounds, which were found to be irreversible inhibitors of the hCMV UL70 primase based on

Arylsulfonic acid salts of pyrimidine-based antiviral

Salts of pyrimidine derivatives are provided having the formula: wherein R represents hydrogen, methyl or ethyl; Z represents a substituted or unsubstituted 1-piperidinyl, a substituted or unsubstituted 4-morpholinyl, or a substituted or unsubstituted 1-pyrrolidinyl; and Ar represents a substituted or unsubstituted phenyl or a substituted or unsubstituted naphthyl. These salts are particularly useful as antiviral agents (e.g., to treat CMV infections).