- Preparation method of N- phenyl-2-aminopyrimidine compound and its application
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The invention relates to a new N- phenyl-2-aminopyrimidine compound and a medicine composition containing the compound; the N- phenyl-2-aminopyrimidine compound is applied to treat related disease or symptoms of epidermal growth factor receptor (EGFR), such as treat or improve abnormal cell proliferative disease like cancer.
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Paragraph 0213; 0224; 0225; 0226
(2017/04/28)
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- N-Heterocyclic carbenes derived from imidazo-[1,5-a]pyridines related to natural products: synthesis, structure and potential biological activity of some corresponding gold(I) and silver(I) complexes
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A series of Au(I) complexes (12, 13, 14, 15, 16) and Ag(I) complexes (17, 18, 19, 20) derived from imidazo[1,5-a]pyridin-3-ylidenes were synthesized from AuCl(SMe2) or by reacting silver(I) acetate with 2,5-dimethylimidazo[1,5-a]pyridin-2-ium iodide or imidazo[1,5-a]pyridin-2-ium salts, and were characterized using NMR spectroscopy, mass spectrometry and elemental analyses. In addition, the Au(I) complex 13 and the Ag(I) complex 19 were characterized using single-crystal X-ray diffraction. Using paclitaxel as a standard, all Au(I) and Ag(I) N-heterocyclic carbene complexes were evaluated for their in vitro anti-tumour activity against 12 cell lines using a monolayer cell survival and proliferation assay. The highest anticancer activity was found for complexes 15, 13 and 14 with mean IC50 values of 10.09, 10.42 and 12.28?μM, respectively. Copyright
- Mihorianu, Monica,Franz, M Heiko,Jones, Peter G,Freytag, Matthias,Kelter, Gerhard,Fiebig, Heinz-Herbert,Tamm, Matthias,Neda, Ion
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p. 581 - 589
(2016/07/16)
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- Substituted imidazo[1,5-A]pyridines
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Disclosed are e.g. novel 5-(carboxyalkyl)imidazo[1,5-a]pyridines, their derivatives and methods of synthesis. Said compounds are useful as selective thromboxane synthetase inhibitors for the treatment of diseases such as cerebral ischaemia, shock, thrombo
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- A DIRECT METHOD FOR THE SUBSTITUTION OF IMIDAZOPYRIDINES AT POSITION 5
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3-Ethylthioimidazopyridine lithiates at carbon 5.Quenching of the anion with an electrophile followed by desulphurisation gives 5-substituted imidazopyridines.
- Blatcher, Philip,Middlemiss, David
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p. 2195 - 2196
(2007/10/02)
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