N-Methylative aziridine ring opening: Asymmetric synthesis of hygroline, pseudohygroline, and hygrine
Asymmetric syntheses of biologically and pharmaceutically important (-)-hygroline, (-)-pseudohygroline, and (-)-hygrine were achieved by a newly developed 'N-methylative aziridine ring opening reactions' of (2S)-methoxycarbonylethylaziridine as a key step.
Lee, Jaedeok,Lee, Jae Eun,Ha, Hyun-Joon,Son, Se In,Lee, Won Koo
Synthetic studies of alkaloids containing pyrrolidine and piperidine structural motifs
Avenues to asymmetric alkaloids! Various 2-substituted pyrrolidine and piperidine chiral bioactive natural products were synthesized using a 'chiral pool' method. l-proline and l-pipecolinic acids with one chiral center served as the best precursors for the synthesis of these alkaloids. Overall, 14 total synthetic and 11 formal synthetic approaches were developed.
Bhat, Chinmay
p. 192 - 196
(2015/04/27)
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