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α-Tosyl-(2,4-difluorobenzyl)isocyanide is a chemical compound that features a tosyl group, a difluorobenzyl group, and an isocyanide group. It is recognized for its utility in organic synthesis, serving as a valuable building block for the creation of a diverse range of organic compounds.

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  • 660431-66-3 Structure
  • Basic information

    1. Product Name: α-Tosyl-(2,4-difluorobenzyl)isocyanide
    2. Synonyms: α-Tosyl-(2,4-difluorobenzyl)isocyanide;a-Tosyl-(2,4-difluorobenzyl)isocyanide;2,4-Difluoro-1-(isocyano(tosyl)methyl)benzene;2,4-Difluoro-1-[isocyano-(toluene-4-sulfonyl)-methyl]-benzene;2,4-difluoro-1-[isocyano[(4-methylphenyl)sulfonyl]methyl]benzene
    3. CAS NO:660431-66-3
    4. Molecular Formula: C15H11F2NO2S
    5. Molecular Weight: 307.319
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 660431-66-3.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: α-Tosyl-(2,4-difluorobenzyl)isocyanide(CAS DataBase Reference)
    10. NIST Chemistry Reference: α-Tosyl-(2,4-difluorobenzyl)isocyanide(660431-66-3)
    11. EPA Substance Registry System: α-Tosyl-(2,4-difluorobenzyl)isocyanide(660431-66-3)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 660431-66-3(Hazardous Substances Data)

660431-66-3 Usage

Uses

Used in Organic Synthesis:
α-Tosyl-(2,4-difluorobenzyl)isocyanide is used as a versatile building block for the synthesis of various organic compounds, contributing to the development of new chemical entities.
Used in Pharmaceutical Industry:
α-Tosyl-(2,4-difluorobenzyl)isocyanide is used as a reagent in the synthesis of pharmaceuticals, aiding in the production of drugs with potential therapeutic applications.
Used in Agrochemical Industry:
α-Tosyl-(2,4-difluorobenzyl)isocyanide is used as a component in the preparation of agrochemicals, such as pesticides and herbicides, to enhance crop protection and yield.
Used in the Synthesis of Heterocycles:
α-Tosyl-(2,4-difluorobenzyl)isocyanide is used as an effective reagent for the synthesis of various heterocycles, which are important in the development of complex molecular structures with potential applications in different fields.
Safety Consideration:
It is important to handle α-Tosyl-(2,4-difluorobenzyl)isocyanide with care, as isocyanides are known to be toxic and can pose a risk to human health. Proper safety measures should be implemented during its use in laboratories and industrial settings.

Check Digit Verification of cas no

The CAS Registry Mumber 660431-66-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,6,0,4,3 and 1 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 660431-66:
(8*6)+(7*6)+(6*0)+(5*4)+(4*3)+(3*1)+(2*6)+(1*6)=143
143 % 10 = 3
So 660431-66-3 is a valid CAS Registry Number.

660431-66-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name 2,4-difluoro-1-[isocyano-(4-methylphenyl)sulfonylmethyl]benzene

1.2 Other means of identification

Product number -
Other names A8929

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:660431-66-3 SDS

660431-66-3Relevant articles and documents

A 4 - methoxy pyrrole intermediate preparation method

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, (2019/07/10)

The present invention provides 4 - methoxy pyrrole intermediate preparation method, comprises the following steps: (1) of formula (I) compound 2, 4 - difluorobenzaldehyde with formula (II) compound to the [...] sulfonic acid in the alkaline solvent and th

DI AND TRIFLUORO-TRIAZOLO-PYRIDINES ANTI-INFLAMMATORY COMPOUNDS

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Page 52, (2008/06/13)

The present invention relates to novel triazolo-pyridines of the formula (I) wherein R1 is fluoro; s is an integer from two to three; R2 is (C3-C6)cycloalkyl optionally substituted by one or two moieties independently selected from the group consisting of halo, (Cl-C4)alkyl, hydroxy, (Cl-C6)alkoxy and (C1-C6)alkyl-(C=O)-0-; or R2 is (Cl-C6)alkyl optionally substituted by one or two moieties independently selected from the group consisting of halo, (C1-C6)alkyl, hydroxy, (C1-C6)alkoxy and (C1-C6)alkyl-(C=O)-0-; with the proviso that said compound of formula (I) cannot be 6-[4-(2,4-Difluoro-phenyl)-oxazol-5-yl]-3-isopropyl-[1,2,4]triazolo[4,3-a]pyridine; or 6-[4-(3,4-Difluoro-phenyl)-oxazol-5-yl]-3-isopropyl-[1,2,4]triazolo[4,3-a]pyridine; to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use. The compounds of the present invention are potent inhibitors of MAP kinases, preferably p38 kinase. They are useful in the treatment of inflammation, osteoarthritis, rheumatoid arthritis, cancer, repurfusion or ischemia in stroke or heart attack, autoimmune diseases and other disorders.

Cycloalkyl-[4-(difluorophenyl)-oxazol-5-yl]-triazolo-pyridines

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Page 21, (2010/02/06)

The present invention relates to novel cycloalkyl-[4-(difluorophenyl)-oxazol-5-yl]triazolo-pyridines, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use. The compounds of the present invention are potent inhibitors of MAP kinases, preferably p38 kinase. They are useful in the treatment of inflammation, osteoarthritis, rheumatoid arthritis, cancer, reperfusion or ischemia in stroke or heart attack, autoimmune diseases and other disorders.

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