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CAS

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66374-23-0

3-(4-Methoxybenzyl)phthalide is a synthetic organic compound characterized by its unique molecular structure, featuring a phthalide core with a 4-methoxybenzyl substituent. 3-(4-Methoxybenzyl)phthalide exhibits a range of biological activities and has been extensively studied for its potential therapeutic applications.

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  • 66374-23-0 Structure

  • Basic information

    1. Product Name: 3-(4-Methoxybenzyl)phthalide
    2. Synonyms: 3-(4-Methoxybenzyl)phthalide;3-(p-Methoxybenzyl)phthalide;3-[(4-Methoxyphenyl)Methyl]-1(3H)-isobenzofuranone
    3. CAS NO:66374-23-0
    4. Molecular Formula: C16H14O3
    5. Molecular Weight: 254.28056
    6. EINECS: N/A
    7. Product Categories: Aromatics;Heterocycles;Intermediates
    8. Mol File: 66374-23-0.mol

  • Chemical Properties

    1. Melting Point: 87-88 °C
    2. Boiling Point: 425.7±38.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.220±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: Chloroform, Dichloromethane, Methanol
    9. CAS DataBase Reference: 3-(4-Methoxybenzyl)phthalide(CAS DataBase Reference)
    10. NIST Chemistry Reference: 3-(4-Methoxybenzyl)phthalide(66374-23-0)
    11. EPA Substance Registry System: 3-(4-Methoxybenzyl)phthalide(66374-23-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 66374-23-0(Hazardous Substances Data)

66374-23-0 Usage

Uses

Used in Pharmaceutical Industry:
3-(4-Methoxybenzyl)phthalide is used as a reagent for the preparation of drugs targeting Alzheimer's disease and other neurotic disorders. Its neuroprotective properties and ability to modulate various signaling pathways make it a promising candidate for the development of novel therapeutic agents.
Used in Drug Synthesis:
3-(4-Methoxybenzyl)phthalide serves as a key intermediate in the synthesis of various pharmaceutical compounds, particularly those with potential applications in the treatment of neurological disorders. Its unique chemical structure allows for the development of innovative drug candidates with improved efficacy and safety profiles.

Check Digit Verification of cas no

The CAS Registry Mumber 66374-23-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,6,3,7 and 4 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 66374-23:
(7*6)+(6*6)+(5*3)+(4*7)+(3*4)+(2*2)+(1*3)=140
140 % 10 = 0
So 66374-23-0 is a valid CAS Registry Number.

66374-23-0Relevant articles and documents

Photoredox-Catalyzed Generation of Acetonyl Radical in Flow: Theoretical Investigation and Synthetic Applications

Anselmo, Manuel,Basso, Andrea,Protti, Stefano,Ravelli, Davide

, p. 2493 - 2500 (2019/03/08)

A hydrogen atom transfer (HAT) step from acetone allowed the smooth generation of acetonyl radical that was then exploited as synthon in the mild formation of C-C bonds under flow conditions. The process was promoted by aryl radicals photocatalytically generated via single-electron transfer (SET) reduction of arenediazonium salts. The mechanism has been investigated by a combined experimental and computational approach and further supported by deuterium labeling experiments.

Photocatalyzed synthesis of isochromanones and isobenzofuranones under batch and flow conditions

Anselmo, Manuel,Moni, Lisa,Ismail, Hossny,Comoretto, Davide,Riva, Renata,Basso, Andrea

supporting information, p. 1456 - 1462 (2017/08/02)

Photocatalyzed reactions of 2-(alkoxycarbonyl)benzenediazonium tetrafluoroborates with various alkenes afforded isochromanones in good yields, according to a mechanism that was investigated. The advantage of using highly soluble esters rather than carboxylic acids as starting compounds became evident when the reactions were performed under flow conditions. On the other hand, when 2-vinylbenzoic acid derivatives were employed as reagents, isobenzofuranones were obtained together with unprecedented benzo[e][1,3]oxazepin-1(5H)-ones, with the latter derived from incorporation of the solvent (acetonitrile).

Formation od some 3-Aryl-3,4-dihydroisocoumarins by Thermal Ring Closure of Stilbene-2-carboxylic Acids

Bellinger, Geoffrey C. A.,Campbell, William E.,Giles, Robin G. F.,Tobias, Julius D.

, p. 2819 - 2826 (2007/10/02)

When heated at 200 deg C, cis- and trans-4'- and 2'-methoxystilbene-2-carboxylic acids have been converted into the title compounds in varying yields, as has trans-4'-hydroxystilbene-2-carboxylic acid.On the other hand, trans-4'-nitrostilbene-2-carboxylic acid affords 3-(4-nitrobenzyl)phthalide.Mass spectrometry provides a simple method of distinguishing between the dihydroisocoumarins and phthalides.

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