66374-13-8

Upstream product

• 68692-70-6 (Z)-4'-Methoxy-2-methoxycarbonylstilbene 
• 66374-13-8 2-[2-(4-methoxyphenyl)ethenyl]benzoic acid 
• 610-97-9 o-iodo-methyl-benzoic acid 
• 48121-13-7 copper(I) 4-methoxyphenylacetylenide 
• 130818-20-1 2-(2-(4-methoxyphenyl)ethynyl)benzoic acid methyl ester 
• 66374-23-0 3-(4-methoxyphenylmethyl)isobenzofuran-1(3H)-one 
• 68692-62-6 methyl 2-[(E)-2-(4-methoxyphenyl)ethenyl]benzoate 
• 1194-57-6 2-thiophthalide 
• 123-11-5 4-methoxy-benzaldehyde 
• 87-24-1 ethyl 2-methylbenzoate 
• 637-69-4 4-Methoxystyrene 
• 65-85-0 benzoic acid 
• 27326-44-9 methyl o-vinylbenzoate 

Downstream Products

• 14525-71-4 2-<3-(4-methoxyphenyl)ethyl>benzoic acid 
• 37568-81-3 3,4-dihydro-3-(4-methoxyphenyl)-1H-2-benzopyran-1-one 
• 66374-15-0 2-Diazo-1-{2-[(Z)-2-(4-methoxy-phenyl)-vinyl]-phenyl}-ethanone 
• 29910-92-7 3-(4-methoxyphenyl)-1H-isochromen-1-one 
• 1354004-87-7 (3S,4R)-4-bromo-3-(4-methoxyphenyl)-3,4-dihydroisochromen-1-one 
• 66374-14-9 2-Diazo-1-{2-[(E)-2-(4-methoxy-phenyl)-vinyl]-phenyl}-ethanone 

Relevant academic research and scientific papers

Directed C-H Bond Functionalization: A Unified Approach to Formal Syntheses of Amorfrutin A, Cajaninstilbene Acid, Hydrangenol, and Macrophyllol

Formal syntheses of natural products amorfrutin A, cajaninstilbene acid, hydrangenol, and macrophyllol have been accomplished on the basis of successive C-H bond functionalization of ready-stock benzoic acids. This concise strategy involves transition-metal-catalyzed directed C-H olefination, C-H hydroxylation, and acid-mediated C-H prenylation as key steps.

Reactivity of Anodically Generated 4-Methoxystilbene Cation Radicals: The Influence of Ortho-Substituted Hydroxymethyl, Aminomethyl, and Carboxylic Acid Groups

The effect of ortho′-substituted side chains bearing nucleophilic groups such as CH2OH, CH2NHR, and CO2H on the reactivity of anodically generated 4-methoxy- and 3,4-dimethoxystilbene cation radicals was investigated, and results were compared with those of substrates where the nucleophilic groups such as OH and NHR are directly attached to the aromatic ring. It was found that when ortho′-substituted groups such as CH2OH or CH2NHR are present in the other ring, only direct intramolecular cation-nucleophile reactions occur to give bisbenzopyrans or bisisoquinolines. Crossover products (previously obtained when the ortho′ substituents were OH and NH2) such as the fused benzoxepanes/fused benzoazepanes were not formed. When the ortho′ substituent is COOH, direct intramolecular cation-nucleophile reaction occurs to give the corresponding bis-δ-lactones in high yield. The presence of an additional 3-methoxy substituent resulted in the formation of other fused polycyclic products due to competing aromatic substitution reactions. Reaction pathways leading to the different products and reasons for the difference in behavior shown by the present stilbenes are presented. The results have provided additional insight into the reactivity and behavior of anodically generated stilbene cation radicals.

An Easy-to-Machine Electrochemical Flow Microreactor: Efficient Synthesis of Isoindolinone and Flow Functionalization

Flow electrochemistry is an efficient methodology to generate radical intermediates. An electrochemical flow microreactor has been designed and manufactured to improve the efficiency of electrochemical flow reactions. With this device only little or no supporting electrolytes are needed, making processes less costly and enabling easier purification. This is demonstrated by the facile synthesis of amidyl radicals used in intramolecular hydroaminations to produce isoindolinones. The combination with inline mass spectrometry facilitates a much easier combination of chemical steps in a single flow process.

Stereoselective synthesis of hydroxy stilbenoids and styrenes by atom-efficient olefination with thiophthalides

The synthesis of stilbenoids and styryl carboxylic acids is accomplished with high E-stereoselectivity by olefination of aldehydes with thiophthalides under basic conditions. The olefination is highly atom-efficient as it only loses elemental sulfur during the reaction. This olefination, in conjunction with retro Kolbe-Schmitt reaction, allows facile synthesis of E-hydroxystilbenoids with minimal employment of protecting groups. This study also discloses two important findings: formation of i) 4-methylsulfanyl isocoumarins and ii) an 2-arylindenone. The Royal Society of Chemistry 2012.

Selenium-mediated synthesis of biaryls through rearrangement

"Chemical Equation Presented" A new cyclization of β-keto ester substituted stilbene derivatives using selenium electrophiles in the presence of Lewis acids is described. Substituted naphthols are obtained through cyclization and subsequent 1,2-rearrangement of aryl groups under very mild reaction conditions.

Diselenide- and disulfide-mediated synthesis of isocoumarins

Cyclizations of stilbenecarboxylic acids to the corresponding isocoumarin derivatives using diselenide or disulfide reagents have been developed. By employing bis(triflouroacetoxy)iodobenzene as oxidant for the 6-endo-trig cyclizations a variety of dihydroisocoumarins have been prepared in good yields. This method is capable of forming isocoumarins and dihydroisocoumarin derivatives by a cyclization-elimination route.

DIBENZOCYCLOHEPTENE COMPOUND

The present invention discloses a dibenzocycloheptene compound represented by the formula (I): ???wherein R1: hydrogen atom, halogen atom, etc., R2: hydrogen atom, halogen atom, etc., A: 5-membered or 6-membered heteroaromatic ring group containing 1 to 3 hetero atom(s) selected from the group consisting of nitrogen atom, oxygen atom and sulfur atom, and the heteroaromatic ring group, etc. may have halogen atom, nitrogen atom, etc. as substituent(s), B: formula; -CH=CH-, formula; -CH2O-, etc., Y: C1-C10 alkylene group which may have halogen atom, etc. as substituent(s), etc., Z: carboxyl group which may be protected, etc., m: an integer of 1 to 4, n: an integer of 1 to 3, ???------ represents a single bond or a double bond, or a pharmaceutically acceptable salt thereof and a medical composition containing the same as an effective ingredient which has leukotriene C4 antagonistic action and leukotriene E4 antagonistic action in addition to potent leukotriene D4 antagonistic action, and useful as antiasthmatic agent, antiallergic agent and anti-inflammatory agent.

Transmission of Polar Effects. Part 21. Alkaline Hydrolysis of the 2'- and 4'-substituted 2-Methoxycarbonyldiphenylacetylenes and (Z)-2'- and -4'- Substituted 2-Methoxycarbonylstilbenes and the Ionisation and Esterification, with Diazodiphenylmethane of t

The rate coefficients for the alkaline hydrolysis of a series of 2'- and 4'-substituted 2-methoxycarbonyldiphenylacetylenes and (Z)-2-methoxycarbonylstilbenes have been determined in 70percent (v/v) dimethyl sulphoxide-water at both 30.0 and 50.0 deg C an

Formation od some 3-Aryl-3,4-dihydroisocoumarins by Thermal Ring Closure of Stilbene-2-carboxylic Acids

When heated at 200 deg C, cis- and trans-4'- and 2'-methoxystilbene-2-carboxylic acids have been converted into the title compounds in varying yields, as has trans-4'-hydroxystilbene-2-carboxylic acid.On the other hand, trans-4'-nitrostilbene-2-carboxylic acid affords 3-(4-nitrobenzyl)phthalide.Mass spectrometry provides a simple method of distinguishing between the dihydroisocoumarins and phthalides.