669091-09-2Relevant articles and documents
Discovery of novel modulators of metabotropic glutamate receptor subtype-5
Wang, Bowei,Vernier, Jean-Michel,Rao, Sara,Chung, Janice,Anderson, Jeffery J.,Brodkin, Jesse D.,Jiang, Xiaohui,Gardner, Michael F.,Yang, Xiaoqing,Munoz, Benito
, p. 17 - 21 (2007/10/03)
A series of potent and selective mGluR5 antagonists were synthesized and evaluated in vitro and in vivo. It was found that a pyridyl functionality is a potential replacement for acetonitrile in the lead structure, with 2-pyridyl being most favored. Additi