- Controllable synthesis of bis[3-(dimethylamino)propyl]amine over Cr and Co double-doped Cu/Γ-Al2O3
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The continuous synthesis of bis[3-(dimethylamino)propyl]amine (BPA) by hydrogenation of 3-(dimethylamino)-propionitrile (PN) in the presence of 3-(N,N-dimethylamino)propylamine (PA) over copper-based catalysts was investigated. It was found that Cu-Crsub
- Lin, Chenhui,Li, Jiayi,Guo, Haotian,Wu, Xingchun,Wang, Bowei,Yan, Xilong
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- Synthesis method of tetramethyl diene triamine compound
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The invention discloses a synthesis method of a tetramethyl diene triamine compound. The synthesis method comprises the following steps: taking palladium-rhodium graphene (Pd/Rh-CDG) as a catalyst, adding a raw material amine and a raw material nitrile into a reaction kettle, heating the reaction kettle to 90 DEG C in a hydrogen atmosphere under the pressure of 3-8MPa, stirring to react for 2-6 hours, cooling to normal temperature, centrifugally separating a catalyst and a reaction solution, and rectifying the reaction solution under reduced pressure to obtain the product tetramethyl diene triamine compound. The method has the beneficial effects that the catalyst has good compatibility with a reaction system, high activity and high selectivity, the catalyst is simply and thoroughly separated from the reaction system after the reaction is finished, and the catalyst is not obviously inactivated after being continuously used for 10 times. The process is simple, and the catalyst can be recycled. In the synthesis process of tetramethyl dipropylene triamine, the reactant conversion rate can reach 95% or above, and the selectivity of the product tetramethyl dipropylene triamine can reach90% or above.
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Paragraph 0015-0021
(2020/07/06)
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- Selective synthesis of N,N-bis(3-dimethylaminopropyl)amine over Pd/γ-Al2O3
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The synthesis of N,N-bis(3-dimethylaminopropyl)amine (BPA) from 3-(dimethylamino)-propionitrile (PN) and 3-(N,N-dimethylamino)propylamine (PA) over Pd/γ-Al2O3 in autoclaves was investigated. A series of Pd catalysts were prepared by different methods and characterized by XRD, TEM, and N2 adsorption–desorption. It was found that their activities were obviously affected by calcination temperature and reducing agent. Among them, the catalyst calcined at 500°C and reduced with NaBH4 exhibited the best performance in this reaction. It was possibly attributed to the better dispersion of palladium particles on γ-Al2O3. Furthermore, reaction parameters were also optimized. Under optimal conditions (PN/PA molar radio 1:1, toluene as solvent), BPA was obtained in 87.9% yield with 95.6% conversion over the above catalyst. Meanwhile, split of PN was observed. A probable mechanism of retro-Michael reaction was also proposed.
- Lin, Chenhui,Wang, Bowei,Guo, Haotian,Chen, Ligong,Yan, Xilong
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p. 391 - 396
(2018/02/21)
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- METHOD FOR PRODUCING BIS-[(3-DIMETHYLAMINO)PROPYL]AMINE (BISDMAPA)
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The invention relates to a method for producing bis-[(3-dimethylamino)propyl]amine (bisDMAPA) by continuously reacting 3-(N,N-dimethylamino)propylamine (DMAPA) in the presence of a heterogeneous catalyst. The inventive method is characterized by carrying out the reaction in a reaction column.
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Page/Page column 3; 9
(2008/06/13)
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- METHOD FOR INCREASING THE SPACE-TIME YIELD IN A PROCESS USED FOR THE PRODUCTION OF A SYMMETRIC SECONDARY AMINE
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Disclosed is a method for increasing the space-time yield in a process that is used for producing a symmetric secondary amine by reacting a primary amine in the presence of hydrogen and a catalyst at a temperature ranging between 50 and 250 °C and an absolute pressure ranging from 5 to 350 bar. According to the inventive method, the absolute pressure is lowered while the temperature is maintained at the same level.
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Page/Page column 13-15
(2008/06/13)
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- Low pressure process for manufacture of 3-dimethylaminopropylamine (DMAPA)
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An improved process for the production of 3-dimethylaminopropylamine in high purity from N,N-dimethylaminopropionitrile utilizing a low pressure hydrogenation process is described. The basic process comprises contacting the nitrile with hydrogen at low pressure in the presence of a catalyst under conditions sufficient to effect the conversion of the nitrile to the primary amine product.
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- Process for the preparation of a symmetrical secondary amine
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Preparation of symmetrical secondary amine (I) comprises reacting a primary amine (II) in the presence of hydrogen over a catalyst (A) prepared by precipitation of catalytically active components (X) on monoclinic, tetragonal or cubic zirconium dioxide.
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- Preparation of a symmetrical secondary amine
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Process for preparing a symmetrical secondary amine by reaction of a primary amine in the presence of hydrogen and a catalyst whose preparation has involved precipitation of catalytically active components onto monoclinic, tetragonal or cubic zirconium dioxide.
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- Tetracyclic benzimidazole derivatives and combinatorial libraries thereof
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The present invention relates to novel tetracyclic benzimidazole derivative compounds of the following formula: wherein R1to R10have the meanings described in here. The invention further relates to combinatorial libraries containing two or more such compounds, as well as methods of preparing tetracyclic benzimidazole derivative compounds.
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- Preparation of secondary amines from nitriles
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Secondary amines of the formula (II) (X—CH2—)2NH??(II) where X is a C1-20-alkyl, C2-20-alkenyl or C3-8-cycloalkyl group which may be unsubstituted or substituted by C1-20-alkyl, C3-8-cycloalkyl, C4-20-alkylcycloalkyl, C4-20-cycloalkylalkyl, C2-20-alkoxyalkyl, C6-14-aryl, C7-20-alkylaryl, C7-20-aralkyl, C1-20-alkoxy, hydroxy, C1-20-hydroxyalkyl, amino, C1-20-alkylamino, C2-20-dialkylamino, C2-12-alkenylamino, C3-8-cycloalkylamino, arylamino, diarylamino, aryl-C1-8-alkylamino, halogen, mercapto, C2-20-alkenyloxy, C3-8-cycloalkoxy, aryloxy and/or C2-8-alkoxycarbonyl, are prepared by reacting nitriles of the formula (III) X—CN??(III) with hydrogen at from 20 to 250° C. and pressures of from 60 to 350 bar in the presence of an Rh-containing catalyst comprising from 0.1 to 5% by weight, based on the total weight of the catalyst, of Rh on a support to give mixtures of primary amines of the formula (I) X—CH2—NH2??(I) and secondary amines of the formula (II) (X—CH2—)2NH??(II) and returning at least part of the primary amines separated from the mixtures obtained to the reaction.
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- Pigment dispersants, pigment dispersions and writing or recording pigment inks
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Dispersants for organic pigments comprise compounds represented by the following formula (I): wherein X and X′ each independently represent H, OH, alkoxy, primary, secondary or tertiary amino, or acylamino; Y represents an anthraquinonylamino, phenylamino or phenoxy group having H, OH, alkoxy, primary, secondary or tertiary amino, or acylamino at the 4-position or 5-position; A and B each independently represent alkyl, cycloalkyl or aryl, and at least one of A and B has at least one substituent group containing a basic nitrogen atom; and Z represents H, CN, halogen, alkyl, alkoxy, NO2, benzoylamino or 3-benzoyl, and the 3-benzoyl group may be fused together with X to form an acridone ring. Pigment dispersions making use of the above dispersants are suited for the production of writing or recording pigment inks.
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- Polyamine analogues with antitumor activity
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A series of tetraamines derived from 1,8-diaminooctane was prepared and tested as antitumor agents. The reaction of 1,8-diaminooctane with acrylonitrile gave N,N'-bis(cyanoethyl)-1,8-diaminooctane, which was reduced to tetraamine 20. Alkylation of the terminal nitrogen atoms of the tetra-Boc derivative of this compound by methyl or ethyl halide followed by removal of the Boc groups gave the bis(alkyl)polyamines 26a and 26b, respectively. These three compounds exhibit promising antitumor activity in the mouse L1210 leukemia model. Coadministration of a polyamine oxidase inhibitor potentiated the antitumor activity.
- Edwards,Prakash,Stemerick,Sunkara,Bitonti,Davis,Dumont
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p. 1369 - 1375
(2007/10/02)
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