67309-36-8

Basic information

• Product Name: 1-PHENYL-2-AMINOHEXANE
• Synonyms: 1-PHENYL-2-AMINOHEXANE
• CAS NO: 67309-36-8
• Molecular Formula: C₁₂H₁₉N
• Molecular Weight: 177.29
• Mol File: 67309-36-8.mol

Chemical Properties

• Boiling Point: 266.2°C at 760 mmHg
• Flash Point: 111.6°C
• Appearance: /
• Density: 0.921g/cm³
• Vapor Pressure: 0.00874mmHg at 25°C
• Refractive Index: 1.513
• PKA: 10.91±0.35(Predicted)
• CAS DataBase Reference: 1-PHENYL-2-AMINOHEXANE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-PHENYL-2-AMINOHEXANE(67309-36-8)
• EPA Substance Registry System: 1-PHENYL-2-AMINOHEXANE(67309-36-8)

Safety Data

• Hazardous Substances Data: 67309-36-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H19N/c1-2-3-9-12(13)10-11-7-5-4-6-8-11/h4-8,12H,2-3,9-10,13H2,1H3

Upstream product

• 110-59-8 pentanonitrile 
• 6921-34-2 benzylmagnesium chloride 
• 592-41-6 1-hexene 
• 25870-62-6 1-phenyl-2-hexanone 
• 71535-50-7 N-tosyl-2-benzylaziridine 
• 300-57-2 allylbenzene 
• 124664-54-6 C₁₈H₂₂N₂ 
• 141765-79-9 α-Pentanoyl-α-phenyl-acetonitril 

Downstream Products

• 848135-62-6 (+/-)-N-(methoxycarbonyl)-1-phenyl-2-aminohexane 
• 553678-92-5 C₁₉H₂₃N 

Relevant articles and documents

MOF-derived cobalt nanoparticles catalyze a general synthesis of amines

The development of base metal catalysts for the synthesis of pharmaceutically relevant compounds remains an important goal of chemical research. Here, we report that cobalt nanoparticles encapsulated by a graphitic shell are broadly effective reductive amination catalysts. Their convenient and practical preparation entailed template assembly of cobaltdiamine- dicarboxylic acid metal organic frameworks on carbon and subsequent pyrolysis under inert atmosphere.The resulting stable and reusable catalysts were active for synthesis of primary, secondary, tertiary, and N-methylamines (more than 140 examples).The reaction couples easily accessible carbonyl compounds (aldehydes and ketones) with ammonia, amines, or nitro compounds, and molecular hydrogen under industrially viable and scalable conditions, offering cost-effective access to numerous amines, amino acid derivatives, and more complex drug targets.

Highly regioselective nickel-catalyzed cross-coupling of N -tosylaziridines and alkylzinc reagents

Herein, we report the first ligand-controlled, nickel-catalyzed cross-coupling of aliphatic N-tosylaziridines with aliphatic organozinc reagents. The reaction protocol displays complete regioselectivity for reaction at the less hindered C-N bond, and the products are furnished in good to excellent yield for a broad selection of substrates. Moreover, we have developed an air-stable nickel(II) chloride/ligand precatalyst that can be handled and stored outside a glovebox. In addition to increasing the activity of this catalyst system, this also greatly improves the practicality of this reaction, as the use of the very air-sensitive Ni(cod)2 is avoided. Finally, mechanistic investigations, including deuterium-labeling studies, show that the reaction proceeds with overall inversion of configuration at the terminal position of the aziridine by way of aziridine ring opening by Ni (inversion), transmetalation (retention), and reductive elimination (retention).

Identification of novel allosteric modulators for the G-protein coupled US28 receptor of human cytomegalovirus

The highly constitutively active G-protein coupled receptor US28 of human cytomegalovirus (HCMV) is an interesting pharmacological target because of its implication on viral dissemination, cardiovascular diseases and tumorigenesis. We found that dihydrois

Exploring the active site of phenylethanolamine N-methyltransferase: 3-alkyl-7-substituted-1,2,3,4-tetrahydroisoquinoline inhibitors

A series of 3-alkyl-7-substituted-1,2,3,4-tetrahydroisoquinolines was synthesized and these compounds were evaluated for their PNMT inhibitory potency and affinity for the α2-adrenoceptor. 7-Nitro-, 7-bromo-, 7-aminosulfonyl-, or 7-N-2,2,2-trif