68700-92-5

Basic information

• Product Name: PYRIDINE, 2-CHLORO-5-(1-METHYLETHENYL)-
• Synonyms: PYRIDINE, 2-CHLORO-5-(1-METHYLETHENYL)-;2-CHLORO-5-(1-METHYLETHENYL) PYRIDINE;2-chloro-5-(prop-1-en-2-yl)pyridine
• CAS NO: 68700-92-5
• Molecular Formula: C8H8ClN
• Molecular Weight: 153.61
• Mol File: 68700-92-5.mol

Chemical Properties

• Boiling Point: 224.178 °C at 760 mmHg
• Flash Point: 110.789 °C
• Appearance: /
• Density: 1.094 g/cm³
• Vapor Pressure: 0.138mmHg at 25°C
• Refractive Index: 1.531
• CAS DataBase Reference: PYRIDINE, 2-CHLORO-5-(1-METHYLETHENYL)-(CAS DataBase Reference)
• NIST Chemistry Reference: PYRIDINE, 2-CHLORO-5-(1-METHYLETHENYL)-(68700-92-5)
• EPA Substance Registry System: PYRIDINE, 2-CHLORO-5-(1-METHYLETHENYL)-(68700-92-5)

Safety Data

• Hazardous Substances Data: 68700-92-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
PYRIDINE, 2-CHLORO-5-(1-METHYLETHENYL)is used as a chemical intermediate for the synthesis of various pharmaceuticals. Its unique structure allows it to be a key component in the development of new drugs, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical industry, PYRIDINE, 2-CHLORO-5-(1-METHYLETHENYL)is utilized as an intermediate in the production of pesticides. Its role in creating effective and targeted pesticides helps to improve crop protection and contribute to sustainable agriculture.
Used in Organic Compounds Synthesis:
PYRIDINE, 2-CHLORO-5-(1-METHYLETHENYL)is also used as an intermediate in the synthesis of other organic compounds. Its versatility in chemical reactions makes it a valuable component in the creation of a wide range of organic molecules for various applications.

InChI:InChI=1/C8H8ClN/c1-6(2)7-3-4-8(9)10-5-7/h3-5H,1H2,2H3

Upstream product

• 68700-91-4 2-chloro-5-(1-hydroxy-1-methylethyl)pyridine 
• 6192-52-5 p-toluenesulfonic acid monohydrate 
• 55676-22-7 3-acetyl-6-chloropyridine 
• 2065-66-9 methyl-triphenylphosphonium iodide 
• 69045-79-0 2-choro-5-iodopyridine 
• 126726-62-3 2-isopropenyl-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane 
• 53939-30-3 5-bromo-2-chloropyridine 

Downstream Products

• 68700-93-6 2-chloro-5-isopropylpyridine 

Relevant articles and documents

QUINOLINE DERIVATIVES AS SMO INHIBITORS

Disclosed are quinoline derivatives as hedgehog pathway inhibitors, especially as SMO inhibitors. Compounds of the present invention can be used in treating diseases relating to hedgehog pathway including cancer.

HISTONE DEMETHYLASE INHIBITORS

The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted pyrido[3,4-d]pyrimidin-4-one derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of histone demethylase. Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as prostate cancer, breast cancer, bladder cancer, lung cancer and/or melanoma and the like.

1-Amino-4-benzylphthalazines as orally bioavailable smoothened antagonists with antitumor activity

Abnormal activation of the Hedgehog (Hh) signaling pathway has been linked to several types of human cancers, and the development of small-molecule inhibitors of this pathway represents a promising route toward novel anticancer therapeutics. A cell-based screen performed in our laboratories identified a new class of Hh pathway inhibitors, 1-amino-4-benzylphthalazines, that act via antagonism of the Smoothened receptor. A variety of analogues were synthesized and their structure-activity relationships determined. This optimization resulted in the discovery of high affinity Smoothened antagonists, one of which was further profiled in vivo. This compound displayed a good pharmacokinetic profile and also afforded tumor regression in a genetic mouse model of medulloblastoma.

Substituted pyridyl compounds, herbicidal compositions and method of use

Substituted pyridyl compounds, e.g. 2,6-dichloro-4(2-(2,2,2-trichloroethyl)oxiranyl) pyridine; herbicidal compositions containing such compounds and method for the control of undesired vegetation using these compositions.

Substituted 11-oxo-11H-pyrido[2,1-b]quinazolines and method of inhibiting allergic reactions with them

Pyrido[2,1-b]quinazolines of the formulas STR1 wherein R1, R1 ', R2, R2 ', R3, R3 ', R4 and R10 are as hereinafter set forth, and processes for the preparation thereof

Pyrido[2,1-b]quinazolinecarboxylic acids as orally active antiallergy agents

A series of 8-substituted pyrido[2,1-b]quinazoline-2-carboxylic acids was prepared by the nickel carbonyl mediated carboxylation of the corresponding bromides. The activities of these compounds in the rat PCA test are comparable to those of the corresponding 2-substituted pyrido[2,1-b]quinazoline-8-carboxylic acids.