68700-91-4

Usage

Structure

A six-membered heterocyclic ring containing five carbon atoms and one nitrogen atom, with a hydroxyl group attached to the second carbon atom of the propan-2-ol (isopropanol) moiety, and a chlorine atom in the 6-position of the pyridine ring.

Type of compound

A secondary alcohol

Usage

In the synthesis of pharmaceuticals and agrochemicals, commonly used as a building block in organic synthesis for the production of various chemicals and materials.

Upstream product

• 58757-38-3 6-Chloronicotinoyl chloride 
• 917-64-6 methyl magnesium iodide 
• 73781-91-6 6-Chloronicotinic acid methyl ester 
• 75-16-1 methylmagnesium bromide 
• 55676-22-7 3-acetyl-6-chloropyridine 
• 49608-01-7 6-chloro-3-pyridinecarboxylic acid ethyl ester 
• 53939-30-3 5-bromo-2-chloropyridine 
• 67-64-1 acetone 
• 676-58-4 methylmagnesium chloride 

Downstream Products

• 68700-92-5 2-chloro-5-(1-methylethenyl)pyridine 
• 843643-03-8 2-(6-aminopyridin-3-yl)propan-2-ol 
• 1428527-65-4 N-(2-(6-(4-bromophenyl)pyridin-3-yl)propan-2-yl)acetamide 
• 1428527-64-3 tert-butyl 2-(6-(4-bromophenyl)pyridin-3-yl)propan-2-ylcarbamate 
• 1428527-63-2 diethyl 4-(5-(2-aminopropan-2-yl)pyridin-2-yl)phenylphosphonate 
• 1428527-66-5 4-(5-(2-(4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamido)propan-2-yl)pyridine-2-yl)phenylphosphonic acid 
• 1436433-22-5 2-(6-(4-bromophenyl)pyridin-3-yl)propan-2-amine 
• 1436433-27-0 tert-butyl 2-(6-(4-(diethoxyphosphoryl)phenyl)pyridin-3-yl)propan-2-ylcarbamate 
• 1436433-35-0 diethyl 4-(5-(2-(4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamido) propan-2-yl)pyridin-2-yl)phenylphosphonate 
• 1360055-95-3 2-(6-chloropyridin-3-yl)-N-ethylpropan-2-amine 

Relevant academic research and scientific papers

INDOLE COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS

Provided herein are compounds of formula (V) that bind to BF3 of an androgen receptor (AR), which can modulate the AR for the treatment of Kennedy's disease.

COMPOUNDS USEFUL AS CSF1 MODULATORS

This invention relates to novel compounds and to pharmaceutical compositions comprising the novel compounds. More specifically, the invention relates to compounds useful as Colony Stimulating Factor 1 Receptor (cFMS) modulators (e.g. cFMS inhibitors). This invention also relates to processes for preparing the compounds, uses of the compounds in treatment and methods of treatment employing the compounds. Specifically, the invention relates to the use of the compounds for the treatment of cancer and autoimmune diseases.

SUBSTITUTED PYRIMIDINES

The present invention relates to substituted pyrimidines useful as HIF prolyl hydroxylase inhibitors to treat anemia and like conditions.

SUBSTITUTED PYRIMIDINES

Disclosed are substituted pyrimidines useful as HIF prolyl hydroxylase inhibitors to treat anemia and like conditions.

Inhibitors of Bruton's Tyrosine Kinase

This application discloses 6-(2-Hydroxymethyl-phenyl)-2-methyl-2H-pyridazin-3-one derivatives according to generic Formula I: wherein, variables X, R, and Y4, are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation, such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formula I and at least one carrier, diluent or excipient.

cMET INHIBITORS

Compounds of the following formula are provided for use with cMET: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.

DIPEPTIDYL PEPTIDASE IV INHIBITOR

A compound represented by general formula (I):A-B-D whereinA represents a substituted or unsubstituted 1-pyrrolidinyl group, a substituted or unsubstituted 3-thiazolidinyl group, a substituted or unsubstituted 1-oxo-3-thiazolidinyl group, or the like;B r

Pyrido[2,1-b]quinazolinecarboxylic acids as orally active antiallergy agents

A series of 8-substituted pyrido[2,1-b]quinazoline-2-carboxylic acids was prepared by the nickel carbonyl mediated carboxylation of the corresponding bromides. The activities of these compounds in the rat PCA test are comparable to those of the corresponding 2-substituted pyrido[2,1-b]quinazoline-8-carboxylic acids.