688363-73-7

Basic information

• Product Name: 8-Bromo-2,2-dimethyl-4H-benzo[1,4]oxazin-3-one
• Synonyms: 8-Bromo-2,2-dimethyl-4H-benzo[1,4]oxazin-3-one;8-Bromo-2,2-dimethyl-2H-benzo[b][1,4]oxazin-3(4H)-one
• CAS NO: 688363-73-7
• Molecular Formula: C₁₀H₁₀BrNO₂
• Molecular Weight: 256.1
• Mol File: 688363-73-7.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 8-Bromo-2,2-dimethyl-4H-benzo[1,4]oxazin-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 8-Bromo-2,2-dimethyl-4H-benzo[1,4]oxazin-3-one(688363-73-7)
• EPA Substance Registry System: 8-Bromo-2,2-dimethyl-4H-benzo[1,4]oxazin-3-one(688363-73-7)

Safety Data

• Hazardous Substances Data: 688363-73-7(Hazardous Substances Data)

Upstream product

• 13073-25-1 2-bromo-6-nitro-phenol 
• 28165-50-6 2-amino-6-bromophenol 
• 688363-72-6 2-bromo-N-(3-bromo-2-hydroxyphenyl)-2-methylpropanamide 
• 88-75-5 2-hydroxynitrobenzene 
• 13222-26-9 2-chloroisobutyryl chloride 

Downstream Products

• 853642-86-1 8-bromo-2,2-dimethyl-3,4-dihydro-2H-benzo[1,4]oxazine hydrochloride 
• 853642-88-3 4-[4-(2-fluoro-benzenesulfonyl)-2,2-dimethyl-3,4-dihydro-2H-benzo[1,4]oxazin-8-yl]-piperazine-1-carboxylic acid tert-butyl ester 
• 853642-87-2 8-bromo-4-(2-fluoro-benzenesulfonyl)-2,2-dimethyl-3,4-dihydro-2H-benzo[1,4]oxazine 

Relevant articles and documents

THIAZOLE-SUBSTITUTED AMINOHETEROARYLS AS SPLEEN TYROSINE KINASE INHIBITORS

The invention provides certain thiazole-substituted aminoheteroaryl compounds of the Formula (I) or pharmaceutically acceptable salts thereof, wherein ring R1, R2, R3, R4, ring B, and the subscript r are as defi

3,4-Dihydro-2H-benzo[1,4]oxazine derivatives as 5-HT6 receptor antagonists

A series of novel 3,4-dihydro-2H-benzo[1,4]oxazine derivatives has been designed and synthesized as 5-HT6 receptor antagonists. Many of the compounds displayed subnanomolar affinities for the 5-HT6 receptor and good brain penetration in rats. The relationship of structure and lipophilicity to hERG inhibition of this series of compounds is discussed.

Benzoxazine derivatives and uses thereof

Compounds of the formula (I): or pharmaceutically acceptable salts, solvates or prodrugs thereof, where R1, R2, R3, R4, R5, R6, R7, R8, R9, X, Y and m are as defined herein. Also provided are compositions comprising, methods for using, and methods for preparing compound of formula (I).

Substituted benzoxazinones and uses thereof

The invention provides compound of the Formula: and pharmaceutically acceptable salts or prodrugs thereof, wherein Y, Z, R1, R2, R3, R4, R5, R6, R7, R8, R9,