13222-26-9

Basic information

• Product Name: 2-CHLOROISOBUTYRYL CHLORIDE
• Synonyms: 2-CHLOROISOBUTYRYL CHLORIDE;2-Chloro-2-methylpropionyl chloride;2-chloro-2-methylpropanoyl chloride
• CAS NO: 13222-26-9
• Molecular Formula: C₄H₆Cl₂O
• Molecular Weight: 141
• Mol File: 13222-26-9.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 189.51°C (rough estimate)
• Appearance: /
• Density: 1.1802
• Refractive Index: 1.4369 (estimate)
• CAS DataBase Reference: 2-CHLOROISOBUTYRYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLOROISOBUTYRYL CHLORIDE(13222-26-9)
• EPA Substance Registry System: 2-CHLOROISOBUTYRYL CHLORIDE(13222-26-9)

Safety Data

• Hazardous Substances Data: 13222-26-9(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Journal of the American Chemical Society, 82, p. 2953, 1960 DOI: 10.1021/ja01496a067

Upstream product

• 121-69-7 N,N-dimethyl-aniline 
• 57-15-8 1,1,1-trichloro-2-methyl-2-propanol 
• 91-22-5 quinoline 
• 7782-50-5 chlorine 
• 79-30-1 isobutyryl chloride 
• 56-23-5 tetrachloromethane 
• 7791-25-5 sulfuryl dichloride 
• 94-36-0 dibenzoyl peroxide 
• 7446-70-0 aluminium trichloride 
• 108-90-7 chlorobenzene 
• 594-58-1 2-chloro-2-methylpropanoic acid 
• 594-61-6 2-methyllactic acid 
• 7719-09-7 thionyl chloride 
• 79-31-2 isobutyric Acid 

Downstream Products

• 107773-97-7 1-chloro-2,4-bis-(α-chloro-isobutyryloxy)-benzene 
• 7462-75-1 dimethylcarbamylmethyl chloride 
• 594-58-1 2-chloro-2-methylpropanoic acid 
• 87968-02-3 2-Chloro-2-methyl-1-piperidin-1-yl-propan-1-one 
• 37112-28-0 3-chloro-3-methyl-1-phenyl-2-butanone 
• 688363-73-7 8-bromo-2,2-dimethyl-2H-benzo[b][1,4]oxazin-3(4H)-one 
• 68430-08-0 2-(1-benzyl-4-methyl-1H-pyrazol-3-yloxy)-2-methyl-propionic acid 
• 87968-03-4 N,N-Dibenzyl-2-chloro-2-methyl-propionamide 
• 84394-78-5 C₁₁H₁₃⁽²⁾H 
• 4489-84-3 3-methyl-1-phenylbut-2-ene 
• 116337-70-3 7-acetyl-3-oxo-2,2,4-trimethyl-2,3-dihydro<1,4>benzoxazine 
• 627-97-4 2-methyl-2-heptene 

Relevant articles and documents

Preparation of polymer latex particles carrying salt-responsive fluorescent graft chains

We prepared the novel fluorescent polymer latex particles which can change their fluorescence intensity in response to the increasing NaCl concentration in water. Core polymer latex particles were synthesized by emulsifier-free emulsion polymerization of styrene and 2-(2-chloroisobutyroyloxy)ethyl methacrylate. Hydrophilic polymer chains containing epoxy groups were grafted from the core particles by surface-initiated atom transfer radical copolymerization of methoxy polyethyleneglycol methacrylate (MEOxMA, x = 4 or 9) and glycidyl methacrylate in aqueous media. After azidation of epoxy groups in graft chains, a water-soluble fluorescent dansyl derivative was successfully coupled with the graft chains by copper-catalyzed azide-alkyne cycloaddition in aqueous media. The wavelength of maximum fluorescence intensity of polymer particles carrying graft chains with longer PEG side chains (x = 9) was slightly blue-shifted (7 nm) and the fluorescence intensity increased (1.35 times) with an increase in NaCl concentration as opposed to polymer particles with shorter PEG chains (x = 4).

Preparing method of photoinitiator 2-methyl-2-hydroxy-1-phenylacetone

The invention discloses a preparing method of a photoinitiator 2-methyl-2-hydroxy-1-phenylacetone. The preparing method comprises the steps of conducting acylation reaction on isobutyric acid and phosphorus trichloride, after the reaction is completed, introducing hydrogen chloride gas to make the intermediate state reaction complete, obtaining 2-chloride-2-methyl propionylchloride through chlorination reaction, conducting Friedel-Crafts reaction with benzene in the presence of a catalyst to obtain 2-chloride-2-methyl-1-phenylpropane-1-ketone, and finally after alkaline hydrolysis, washing anddistillation, obtaining the photoinitiator 1173. According to the preparing method, hydrogen chloride is introduced into the acylation step, so that the reaction yield is increased, and byproduct odors are reduced; meanwhile, chlorination reaction of a conventional technology is conducted one step in advance, the production cost of the conventional technology is reduced, and thus the product hasmarket competitiveness.

METHOD FOR PRODUCING UNSATURATED ACID AND/OR UNSATURATED ACID ESTER

The present invention relates to a method for producing an unsaturated acid and/or an unsaturated acid ester, containing a process A of reacting a compound (1) represented by the following formula (1) at a temperature of 0° C. to 350° C. in the presence of a Br?nsted acid catalyst and/or a Lewis acid catalyst, to prepare a compound (2) represented by the following formula (2); in which each of R1, R2 and R4 independently represents a hydrogen atom, a deuterium atom or an alkyl group; each of R3 and R5 independently represents a hydrogen atom or a deuterium atom; R6 represents a hydrogen atom, a deuterium atom, or an alkyl group or an aryl group; and X represents a chlorine atom, a fluorine atom, a bromine atom, or an iodine atom.