69045-86-9

Basic information

• Product Name: 2-(4-methoxyphenoxy)-5-(trifluoromethyl)pyridine
• Synonyms: Pyridine, 2-(4-methoxyphenoxy)-5-(trifluoromethyl)-
• CAS NO: 69045-86-9
• Molecular Formula: C₁₃H₁₀F₃NO₂
• Molecular Weight: 269.2192
• Mol File: 69045-86-9.mol

Chemical Properties

• Boiling Point: 324.2°C at 760 mmHg
• Flash Point: 149.9°C
• Density: 1.277g/cm³
• Vapor Pressure: 0.00047mmHg at 25°C
• Refractive Index: 1.504
• CAS DataBase Reference: 2-(4-methoxyphenoxy)-5-(trifluoromethyl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-methoxyphenoxy)-5-(trifluoromethyl)pyridine(69045-86-9)
• EPA Substance Registry System: 2-(4-methoxyphenoxy)-5-(trifluoromethyl)pyridine(69045-86-9)

Safety Data

• Hazardous Substances Data: 69045-86-9(Hazardous Substances Data)

Upstream product

• 52334-81-3 2-chloro-5-trifluoromethylpyridine 
• 150-76-5 4-methoxy-phenol 
• 887144-94-7 Togni's reagent II 

Downstream Products

• 69045-85-8 2-(4-hydroxyphenoxy)-5-trifluoromethylpyridine 

Relevant articles and documents

Copper-catalyzed trifluoromethylation of organic zinc reagents with an electrophilic trifluoromethylating reagent

A copper-catalyzed trifluoromethylation of aryl, vinyl and alkyl zinc reagents with Togni's reagent was described. Mechanistic studies indicated that the aryl group is initially transferred from the zinc reagent to hypervalent iodine to form a tri-substituted hypervalent iodine intermediate. Consequent reductive-elimination via a concerted bond-forming step and/or radical pathway from this intermediate generates the trifluoromethylated arenes.

Convenient Synthesis of Phenyl Pyridylethers Utilizing Fluoride Ion

Aryl pyridyl ethers were prepared from phenols and active halopyridines under essentially neutral condition via fluoride ion assisted reaction.

Herbicidal pyridine compounds

Herbicidal 3- and/or 5-halogenomethyl-pyrid-2-yloxyphenoxy compounds and processes for making and using the same. Intermediates for making these compounds and their preparation are also disclosed. Thus, for example, 2-chloro-5-trichloromethylpyridine is prepared by a liquid phase chlorination of 3-methylpyridine under the influence of ultra violet light.

Herbicidal compounds

A herbicidal sulphonamide compound of the formula (I): STR1 and salts thereof, wherein R1 is a pyridyl group of the formula: STR2 wherein the group X of the pyridyl group represents a fluorine, chlorine, bromine, or iodine atom, or an alkyl radical of 1 to 4 carbon atoms optionally substituted by one or more fluorine or chlorine atoms, and the group Y represents hydrogen, fluorine chlorine, bromine, or iodine or an alkyl radical of 1 to 4 carbon atoms optionally substituted by one or more fluorine or chlorine atoms; R2 represents an alkyl radical of 1 to 6 carbon atoms optionally substituted by one or more fluorine atoms; and R3 is hydrogen or an alkyl radical of 1 to 4 carbon atoms.

Herbicidal mono- or di-substituted-2-pyridinyloxy-phenoxy-lower-alkane-carbamates

Herbicidal pyridine compounds of the formula (I): STR1 wherein Z may be halogen, or a fluorine- or chlorine-substituted alkyl group of 1 to 4 carbon atoms, and Y may be hydrogen, halogen, or a fluorine- or chlorine-substituted alkyl group of 1 to 4 carbon atoms; X may be an OH group or an acyloxy group; a halogen atom; an amino group, a mono- or di-alkyl amino group, or an alkanoylamido group; an alkoxy group optionally substituted by hydroxy or alkoxy; or a mercapto group, an alkylthio group, or a phenylthio group. The invention also provides herbicidal compositions containing the compounds, and processes for making the compounds.