69045-85-8

Basic information

• Product Name: 4-{[5-(TRIFLUOROMETHYL)PYRIDIN-2-YL]OXY}PHENOL
• Synonyms: 4-{[5-(TRIFLUOROMETHYL)PYRIDIN-2-YL]OXY}PHENOL;4-[[5-(Trifluoromethyl)-2-pyridyl]oxy]phenol
• CAS NO: 69045-85-8
• Molecular Formula: C₁₂H₈F₃NO₂
• Molecular Weight: 255.1926296
• Mol File: 69045-85-8.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 341.9°C at 760 mmHg
• Flash Point: 160.6°C
• Appearance: /
• Density: 1.378g/cm³
• Vapor Pressure: 3.94E-05mmHg at 25°C
• Refractive Index: 1.534
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 4-{[5-(TRIFLUOROMETHYL)PYRIDIN-2-YL]OXY}PHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-{[5-(TRIFLUOROMETHYL)PYRIDIN-2-YL]OXY}PHENOL(69045-85-8)
• EPA Substance Registry System: 4-{[5-(TRIFLUOROMETHYL)PYRIDIN-2-YL]OXY}PHENOL(69045-85-8)

Safety Data

• Hazardous Substances Data: 69045-85-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H8F3NO2/c13-12(14,15)8-1-6-11(16-7-8)18-10-4-2-9(17)3-5-10/h1-7,17H

Upstream product

• 52334-81-3 2-chloro-5-trifluoromethylpyridine 
• 123-31-9 hydroquinone 
• 108-95-2 phenol 
• 69045-86-9 5-(trifluoromethyl)-2-(4-methoxyphenoxy)pyridine 

Downstream Products

• 548763-91-3 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenyl chloroformate 
• 549510-44-3 4-Phenyl-piperazine-1-carboxylic acid 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenyl ester 
• 549512-05-2 4-(Isopropylaminocarbonylmethyl)-piperazine-1-carboxylic acid 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenyl ester 
• 549510-43-2 4-(2-Hydroxyethyl)-piperazine-1-carboxylic acid 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenyl ester 
• 548766-20-7 4-Carbamoyl-piperidine-1-carboxylic acid 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenyl ester 
• 548766-18-3 4-(2-Oxo-2,3-dihydro-benzimidazol-1-yl)-piperidine-1-carboxylic acid 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenyl ester 
• 722454-19-5 4-(Pyrrolidinocarbonylmethyl)-piperazine-1-carboxylic acid 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenyl ester 

Relevant articles and documents

A process for preparing 4 - substituted oxy phenol compounds

The invention belongs to the field of organic synthesis, and relates to a method for preparing a 4-substituted oxyphenol compound. The method comprising the following steps: condensing hydroquinone and a halogen compound in a polar aprotic solvent in a reducing agent and metal alkali system to obtain the 4-substituted oxyphenol compound; removing the solvent after the above reaction, adding a non-polar solvent, filtering, washing, and recovering the raw material hydroquinone; and washing the obtained filtrate through using water, extracting by using an alkaline solution, and adjusting the pH value of the obtained extract solution to obtain the 4-substituted oxyphenol compound. The method has the advantages of short route, simple operation, high selectivity, high yield, good atom economy, high product content, recovery convenience and recycling of the raw material, reduction of three wastes and the cost, and suitableness for industrial production.

ARYLOXY DIHALOPROPENYL ETHER COMPOUNDS AND USES THEREOF

The present invention discloses an aryloxy dihalopropenyl ether compound with the structure shown as general formula (I), of which the group definitions can be seen in the specification. The present invention also discloses the use of the compound with ge

Selective cleavage of aryl methyl ether moiety of aryloxy aryl methyl ether by 48% HBr/tetra-n-butylphosphonium bromide

Aryl methyl ether moiety in the molecule containing aryl aryl ether part along with aryl methyl ether part is selectively cleaved to give the desired substituted phenol in excellent yield by using 48% HBr in the presence of tetra-n-butylphosphonium bromid