69120-07-6

Basic information

• Product Name: Moracin D
• Synonyms: Moracin D
• CAS NO: 69120-07-6
• Molecular Formula: C₁₉H₁₆O₄
• Molecular Weight: 308.32794
• Mol File: 69120-07-6.mol

Chemical Properties

• Boiling Point: 406.9±45.0 °C(Predicted)
• Appearance: /
• Density: 1.295±0.06 g/cm3(Predicted)
• PKA: 9.06±0.40(Predicted)
• CAS DataBase Reference: Moracin D(CAS DataBase Reference)
• NIST Chemistry Reference: Moracin D(69120-07-6)
• EPA Substance Registry System: Moracin D(69120-07-6)

Safety Data

• Hazardous Substances Data: 69120-07-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Moracin D is used as a potential therapeutic agent for various health conditions due to its ability to inhibit cancer cell growth, reduce inflammation, and regulate blood sugar levels.
Used in Natural Medicine:
Moracin D is used as a natural medicine for its anti-allergic and neuroprotective effects, making it a valuable compound in the development of alternative treatments for various health conditions.
Used in Drug Discovery:
Moracin D is used as a compound of interest in drug discovery for its potential to be developed into new pharmaceuticals targeting a range of health issues, including cancer, inflammation, and neurological disorders.

Upstream product

• 1740-74-5 1,1-diethoxy-3-methyl-2-butene 
• 69120-12-3 moracin D diacetate 
• 95-01-2 2,4-Dihydroxybenzaldehyde 
• 52924-53-5 acetic acid 4-formyl-3-hydroxyphenyl ester 
• 41777-08-6 2,4-diacetoxybenzaldehyde 
• 134937-20-5 2-(3,5-dimethoxyphenyl)-6-hydroxybenzofuran 
• 6272-26-0 6-hydroxybenzofuran-3-one 
• 51863-60-6 3,5-dihydroxyacetophenone 
• 108-46-3 recorcinol 
• 218444-38-3 2-(3,5-dimethoxyphenyl)-6-(tert-butyl-dimethylsilanyloxy)benzofuran 
• 299912-77-9 6-(tert-butyl-dimethylsilanyloxy)-[2H]-benzofuran-3-one 
• 69120-06-5 moracin C 

Relevant articles and documents

Functional group manoeuvring for tuning stability and reactivity: Synthesis of cicerfuran, moracins (D, E, M) and chromene-fused benzofuran-based natural products

The protecting group manoeuvring as a strategy was applied for tuning the stability and reactivity of 4-(2,2-dibromovinyl)benzene-1,3-diol (12a) and 6-(2,2-dibromovinyl)-2,2-dimethylchroman-7-ol (22) in the domino synthesis of benzofuran-based natural products (1-8). The functional group demands and their impact on the reactivity driven by electronic effects were successfully managed by varying the protecting groups with substituted gem-dibromovinylphenols in domino couplings and triarylbismuth reagents under palladium-catalyzed conditions. This approach paved the way for the synthesis of moracin M (1) and cicerfuran (2), and the first time synthesis of moracin D (3) and moracin E (4) along with chromene-fused benzofuran-based natural products (5-8) in overall good yields.

Total synthesis of the 2-arylbenzo[b]furan-containing natural products from Artocarpus

In this study, 2-arylbenzo[b]furan-containing derivatives moracin C (1) and moracin M (4), the natural products from Artocarpus, have been synthesized in highest overall yield to date (1, 7 steps with an overall yield of 41.9%; 4, 6 steps with an overall yield of 56.3%), and we also report the first total synthesis of artoindonesianin B-1 (2), another member of this family, in the same route (8 steps with an overall yield of 11.3%). This discovery provides a concise route for preparing enough amounts of 1, 2, and 4 as well as 2-arylbenzo[b]furan-containing natural product-like analogs (71-74) to explore the biological potential.