52924-53-5Relevant articles and documents
Adrenergic receptor agonists. Benzofuranylethanolamines
Lovgren,Hedberg,Nilsson
, p. 624 - 627 (1980)
Two hydroxy-substituted benzofuranylethanolamines (9 and 10), analogues of adrenoceptor-active aryloxypropanolamines, were prepared and their β-adrenoceptor activity was examined. Compound 9 was found to be a β1-selective adrenergic agonist wit
Functional group manoeuvring for tuning stability and reactivity: Synthesis of cicerfuran, moracins (D, E, M) and chromene-fused benzofuran-based natural products
Rao, Maddali L. N.,Murty, Venneti N.,Nand, Sachchida
supporting information, p. 9415 - 9423 (2017/11/23)
The protecting group manoeuvring as a strategy was applied for tuning the stability and reactivity of 4-(2,2-dibromovinyl)benzene-1,3-diol (12a) and 6-(2,2-dibromovinyl)-2,2-dimethylchroman-7-ol (22) in the domino synthesis of benzofuran-based natural products (1-8). The functional group demands and their impact on the reactivity driven by electronic effects were successfully managed by varying the protecting groups with substituted gem-dibromovinylphenols in domino couplings and triarylbismuth reagents under palladium-catalyzed conditions. This approach paved the way for the synthesis of moracin M (1) and cicerfuran (2), and the first time synthesis of moracin D (3) and moracin E (4) along with chromene-fused benzofuran-based natural products (5-8) in overall good yields.
Positional chemoselectivity in the Zn(II)-mediated removal of phenol protecting groups
Fleury, Lauren M.,Gianino, Joseph B.,Ashfeld, Brandon L.
supporting information, p. 5376 - 5379 (2012/10/30)
A protocol was developed for the chemoselective ortho-deprotection of polyphenolic substrates using readily available ZnIIX2 salts. This procedure provides exceptional positional selectivity for the deprotection of phenols that reside adjacent to directing carbonyl functionality in the presence of similar protecting groups at the meta and para positions. Good to excellent yields of the desired free phenols were obtained (≤96%), and a wide assortment of protecting groups was readily removed under the reaction conditions.
BF3·OEt2 mediated regioselective deacetylation of polyacetoxyacetophenones and its application in the synthesis of natural products
Narender,Papi Reddy,Kumar, Brijesh
, p. 4409 - 4415 (2008/12/21)
We have developed an efficient method to regioselectively deacetylate polyacetoxyacetophenones using BF3·OEt2 in excellent yields and demonstrated the application of the procedure in the synthesis of natural products.
PYRAZOLE KINASE MODULATORS AND METHODS OF USE
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Page/Page column 67, (2010/10/20)
The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferationm, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/0r modulate kinases. Methods of using the compounds and pharmaceutical compositions thereof to treat kinase-dependent diseases and conditions are also an aspect of the invention.
Lipase-catalyzed regioselective protection of hydroxyl groups in aromatic dihydroxyaldehydes and ketones
Nicolosi,Piattelli,Sanfilippo
, p. 3143 - 3148 (2007/10/02)
Pseudomonas cepacia lipase catalyzes the acetylation in organic solvent of dihydroxyaldehydes and ketones using vinyl acetate as acyl donor. The method is completely regioselective and allows to obtain partially acetylated compounds different from those obtained by enzymic hydrolysis of polyacetoxy arylaldehydes and ketones.
COUMARINS FROM EDGEWORTHIA CHRYSANTHA
Baba, Kimiye,Tabata, Yuko,Taniguti, Masahiko,Kozawa, Mitsugi
, p. 221 - 226 (2007/10/02)
Two new coumarins, edgeworin and edgeworoside A, were isolated from the root and stem of Edgeworthia chrysantha (E. papyrifera) and their structures determined as 3-(7-coumarinyloxy)-7-hydroxycoumarin and 3-(7-coumarinyloxy)-8-(7-hydroxycoumari-8-yl)-7-α-L-rhamnopyranosyloxycoumarin. - Keywords: Edgeworthia chrysantha; Thymelaeaceae; coumarin; edgeworin; edgeworoside A.
