The Baylis-Hillman chemistry in aqueous media: A convenient synthesis of 2-methylenealkanoates and alkanenitriles
A convenient, general and efficient synthesis of 2-methylenealkanoates and alkanenitriles is accomplished via the regioselective nucleophilic (SN2′) addition of hydride ion from NaBH4 to (2Z)-2-(bromomethyl)alk-2-enoates and 2-(bromomethyl)alk-2-enenitriles respectively in the presence of DABCO in environment friendly aqueous media. Synthesis of two hypoglycemic agents is also described.
Basavaiah, Deevi,Kumaragurubaran, Nagaswamy
p. 477 - 479
(2007/10/03)
Alkylglycidic Acids: Potential New Hypoglycemic Agents
A series of alkylglycidic acid analogues and derivatives were synthesized and tested for their ability to inhibit long-chain fatty acid oxidation in vitro and to lower blood sugar in rats.The extent of inhibition of carnitine acyl transferase, the enzyme
Ho, Winston,Tutwiler, Gene F.,Cottrell, Sandra C.,Morgans, Dave J.,Tarhan, Okan,Mohrbacher, Richard J.
p. 2184 - 2190
(2007/10/02)
Process for production of methyl 2-tetradecylgycidate
An improved process for producing the hypoglycemic compound, methyl 2-tetradecylglycidate, by reacting methyl α-chloropalmitate with lithium methoxide in the presence of formaldehyde in a dipolar aprotic solvent such as DMF or DMSO.
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(2008/06/13)
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