69318-23-6Relevant articles and documents
Subsupercritical Water Generated by Inductive Heating Inside Flow Reactors Facilitates the Claisen Rearrangement
Oltmanns, Mona,Kirschning, Andreas
supporting information, p. 1942 - 1946 (2020/11/13)
Claisen rearrangement of electron-deficient O-allylated phenols, including fluorine-modified phenols, is facilitated in aqueous media at high temperatures and pressures under flow conditions, as opposed to organic solvents. The O-allylation of phenols can be coupled with the Claisen rearrangement in an integrated flow system.
C- ARYL GLYCOSID DERIVATIVES, PHARMACEUTICAL COMPOSITION, PREPARATION PROCESS AND USES THEREOF
-
Paragraph 0191; 0193, (2017/04/19)
This invention relates to a kind of C-aryl glycoside derivatives, its pharmaceutical compositions, preparation methods, and uses thereof. The preparation method comprises: method 1: in a solvent, deprotecting the acetyl protecting groups of compound 1-f in the presence of a base; method 2: 1) compound 2-g reacts with via Mitsunobu reaction; 2) deprotecting the acetyl protecting groups of compound 2-f obtained from step 1; method 3: 1) compound 2-g reacts with via nucleophilic substitution reaction; 2) deprotecting the acetyl protecting groups of compound 3-f obtained from step 1. The pharmaceutical composition comprises a kind of C-aryl glycoside derivatives; it's pharmaceutically acceptable salts and/or prodrugs thereof and excipient thereof. This invention further relates to a kind of C-aryl glycoside derivatives, it's pharmaceutically acceptable salts or pharmaceutical compositions thereof for the use in preparation of a SGLT inhibitor. The C-aryl glycoside derivatives of this invention provides a new direction for the study of SGLT inhibitors.
2 - fluoro - 4 - allyl - 6 - nitro-phenol with 2 - fluoro - 4 - nitro - 6 - allyl phenol joint preparation and use
-
Paragraph 0006; 0012, (2017/10/06)
Disclosed are a combined preparation method and an application of 2-fluoro-4-allyl-6-nitrophenol and 2-fluoro-4-nitro-6-allyl phenol. The combined preparation method comprises the steps: with 2-fluorophenyl allyl ether as a raw material, carrying out Clai
Synthesis and pharmacological evaluation of 2-(1-alkylpiperidin-4-yl)-N- [(1R)-1-(4-fluorophenyl)-2-methylpropyl]acetamide derivatives as novel antihypertensive agents
Watanuki, Susumu,Matsuura, Keisuke,Tomura, Yuichi,Okada, Minoru,Okazaki, Toshio,Ohta, Mitsuaki,Tsukamoto, Shin-Ichi
experimental part, p. 223 - 234 (2012/03/11)
We synthesized and evaluated the inhibitory activity of a series of 2-(1-alkylpiperidin-4-yl)-N-[(1R)-1-(4-fluorophenyl)-2-methylpropyl]acetamide derivatives against T-type Ca2+ channels. Structure-activity relationship studies revealed that th
IMPROVED PROCESS FOR THE PREPARATION OF HALO-DIALKOXYBENZENES
-
Page/Page column 8-9, (2011/06/23)
The invention describes an improved method for producing halo-dialkoxybenzenes of formula (I) such as 1-fluoro-2, 3-dialkoxybenzene as well as 2-fluoro-1, 4-dialkoxybenzene, Formula (I) by reacting commercial 2-fluorophenol is reacted with an allyl halide