69736-37-4Relevant articles and documents
Total synthesis of (-)-4,8,10-tridesmethyl telithromycin
Velvadapu, Venkata,Paul, Tapas,Wagh, Bharat,Glassford, Ian,Debrosse, Charles,Andrade, Rodrigo B.
scheme or table, p. 7516 - 7527 (2011/11/29)
Novel sources of antibiotics are required to address the serious problem of antibiotic resistance. Telithromycin (2) is a third-generation macrolide antibiotic prepared from erythromycin (1) and used clinically since 2004. Herein we report the details of
Stereoselective formal total synthesis of (+)-methynolide
Yadav,Pratap,Rajender
, p. 5882 - 5885 (2008/02/09)
(Chemical Equation Presented) A highly stereoselective and convergent formal total synthesis of (+)-methynolide is described. The salient features of this synthesis have been the construction of the C1-C7 and C8-C11fragments via a desymmetrization approach, Sharpless asymmetric epoxidation of an allyl alcohol, respectively, and linkage of both the fragments by Nozaki-Hiyama-Kishi reaction.
STEREO-SELECTIVE SYNTHESIS OF ERYTHRO-3-METHYL-1-HEXYN-3,4-DIOL
Santelli-Rouvier, Christiane,Santelli, Maurice
, p. 4945 - 4948 (2007/10/02)
A very short stereo-selective preparation of the title compound, an intermediate of methynolide synthesis, is described.