69807-82-5

Basic information

• Product Name: 1H-1,2,4-Triazole-1-propanamine
• Synonyms: 1H-1,2,4-Triazole-1-propanamine;3-(1H-1,2,4-triazol-1-yl)propan-1-amine hydrochloride;3-(1H-1,2,4-triazol-1-yl)propan-1-amine(SALTDATA: 2HCl);[3-(1H-1,2,4-triazol-1-yl)propyl]aMine dihydrochloride (SALTDATA: 2HCl)
• CAS NO: 69807-82-5
• Molecular Formula: C₅H₁₀N₄
• Molecular Weight: 126.1597
• Mol File: 69807-82-5.mol

Chemical Properties

• Boiling Point: 271.5°C at 760 mmHg
• Flash Point: 118°C
• Appearance: /
• Density: 1.24g/cm³
• Vapor Pressure: 0.00644mmHg at 25°C
• Refractive Index: 1.608
• CAS DataBase Reference: 1H-1,2,4-Triazole-1-propanamine(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-1,2,4-Triazole-1-propanamine(69807-82-5)
• EPA Substance Registry System: 1H-1,2,4-Triazole-1-propanamine(69807-82-5)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 69807-82-5(Hazardous Substances Data)

Usage

Uses

Used in Chemical Synthesis:
1H-1,2,4-Triazole-1-propanamine is used as a chemical intermediate for the synthesis of various compounds. Its involvement in multiple chemical reactions allows for the creation of a wide range of products, making it a valuable component in the field of organic chemistry.
Used in Pharmaceutical Industry:
1H-1,2,4-Triazole-1-propanamine is used as a building block in the development of pharmaceutical compounds. Its unique structure and reactivity contribute to the design of new drugs with potential therapeutic applications.
Used in Material Science:
1H-1,2,4-Triazole-1-propanamine is used as a component in the synthesis of advanced materials, such as polymers and coatings. Its incorporation into these materials can impart specific properties, such as improved stability or enhanced performance, depending on the intended application.
Used in Agrochemical Industry:
1H-1,2,4-Triazole-1-propanamine is used as a starting material in the production of agrochemicals, such as pesticides and herbicides. Its chemical properties can be tailored to create effective compounds for use in agriculture to control pests and weeds.

InChI:InChI=1/C5H10N4/c6-2-1-3-9-5-7-4-8-9/h4-5H,1-3,6H2

Upstream product

• 101225-88-1 N-(3-[1,2,4]triazol-1-yl-propyl)-phthalimide 
• 76686-83-4 3-(1H-1,2,4-triazole-1-yl)propanenitrile 
• 288-88-0 1,2,4-Triazole 
• 1336-21-6 ammonium hydroxide 
• 107-13-1 acrylonitrile 
• 83948-53-2 3-bromopropylamine tert-butylcarbamate 

Downstream Products

• 100468-01-7 2-Carboxy-N-[3-(1H-1,2,4-triazol-1-yl)propyl]benzamide 
• 100468-13-1 2-(4-Chloro-phenoxy)-N-(3-[1,2,4]triazol-1-yl-propyl)-acetamide 
• 100468-14-2 (E)-3-(4-Chloro-phenyl)-N-(3-[1,2,4]triazol-1-yl-propyl)-acrylamide 
• 100467-99-0 Biphenyl-2-carboxylic acid (3-[1,2,4]triazol-1-yl-propyl)-amide 
• 100467-95-6 4-Benzoyl-N-(3-[1,2,4]triazol-1-yl-propyl)-benzamide 
• 100467-90-1 3-bromo-N-[3-(1H-1,2,4-triazol-1-yl)propyl]benzamide 
• 100468-27-7 2-(3-Chloro-phenyl)-N-(3-[1,2,4]triazol-1-yl-propyl)-acetamide 
• 100468-26-6 N-(3-[1,2,4]Triazol-1-yl-propyl)-3-trifluoromethyl-benzamide 
• 100467-93-4 4-Butoxy-N-(3-[1,2,4]triazol-1-yl-propyl)-benzamide 
• 100467-89-8 4-fluoro-N-[3-(1H-1,2,4-triazol-1-yl)propyl]benzamide 
• 100467-85-4 3-chloro-N-[3-(1H-1,2,4-triazol-1-yl)propyl]benzamide 
• 100467-97-8 4(dimethylamino)-N-[3-(1H-1,2,4-triazol-1-yl)propyl]benzamide 
• 100467-96-7 4-Acetylamino-N-(3-[1,2,4]triazol-1-yl-propyl)-benzamide 
• 100467-83-2 N-(3-[1,2,4]Triazol-1-yl-propyl)-benzamide 

Relevant articles and documents

Structural Basis for Achieving GSK-3β Inhibition with High Potency, Selectivity, and Brain Exposure for Positron Emission Tomography Imaging and Drug Discovery

Using structure-guided design, several cell based assays, and microdosed positron emission tomography (PET) imaging, we identified a series of highly potent, selective, and brain-penetrant oxazole-4-carboxamide-based inhibitors of glycogen synthase kinase-3 (GSK-3). An isotopologue of our first-generation lead, [3H]PF-367, demonstrates selective and specific target engagement in vitro, irrespective of the activation state. We discovered substantial ubiquitous GSK-3-specific radioligand binding in Tg2576 Alzheimer's disease (AD), suggesting application for these compounds in AD diagnosis and identified [11C]OCM-44 as our lead GSK-3 radiotracer, with optimized brain uptake by PET imaging in nonhuman primates. GSK-3β-isozyme selectivity was assessed to reveal OCM-51, the most potent (IC50 = 0.030 nM) and selective (>10-fold GSK-3β/GSK-3α) GSK-3β inhibitor known to date. Inhibition of CRMP2T514 and tau phosphorylation, as well as favorable therapeutic window against WNT/β-catenin signaling activation, was observed in cells.

BENZOXAZOLE ACETONITRILES

The present invention is related to benzoxazole acetonitriles as well as to pharmaceutical formulations containing such benzoxazole acetonitriles pof formula (I). Said benzoxazole acetonitriles are useful in the treatment of metabolic disorders mediated b

AZOLE METHYLIDENE CYANIDE DERIVATIVES AND THEIR USE AS PROTEIN KINASE MODULATORS

The present invention is related to azole derivatives notably for use as pharmaceutically active compounds, as well as to pharmaceutical formulations containing such azole derivatives. Said azole derivatives are modulators of the protein kinase signalling pathways, particularly the one involving c-Jun N-terminal kinase and/or Glycogen Kinase Synthase 3. The present invention is furthermore related to novel azole derivatives as well as to methods of their preparation. X is O, S or NR0, with R0 being H or an unsubstituted or substituted C1 -C6 alkyl; A is 2-pyridyl, 3-pyridyl, 4-pyridyl, pyridazinyl, pyrimidinyl, pyrazinyl or triazinyl group.

N-[(1H-1,2,4-Triazol-1-yl)alkyl]-arylamides

N-[(1H-1,2,4-Triazol-l-yl)alkyl]arylamides which are inhibitors of thromboxane synthetase enzyme.

N-[(1H-imidazol-1-yl) and (1H-1,2,4-triazol-1-yl)-alkyl]benzenesulfonamides and thromboxane synthetase/antihypertensive compositions

This invention concerns novel N-[(1H-imidazol-1-yl), (1H-1,2,4-triazol-1-yl) and (3-pyridyl)alkyl]benzenesulfonamides which are useful as inhibitors of thromboxane synthetase enzyme and/or as antihypertensive agents.

N-(Substituted phenyl)-N'-[(1H-imidazol-1-yl) and (1H-1,2,4-triazol-1-yl)alkyl]ureas

N-(Substituted phenyl)-N'-[(1H-imidazol-1-yl) and (1H-1,2,4-triazol-1-yl)alkyl]ureas which are inhibitors of thromboxane synthetase enzyme.

Substituted N-[(1H-1,2,4-triazol-1-yl)-alkyl]heteroarylcarboxamides

Substituted N-[(1H-1,2,4-triazol-1-yl)-alkyl]heteroarylcarboxamides are inhibitors of thromboxane synthetase enzyme.

Thromboxane synthetase enzyme inhibiting N-[(1H-imidazol-1-yl) and (1H-1,2,4-triazol-1-yl)alkyl]pyridinecarboxamides

This invention concerns novel N-[(1H-imidazol-1-yl) and (1H-1,2,4-triazol-1-yl)alkyl]pyridinecarboxamides which are useful as inhibitors of thromboxane synthetase and/or as hypotensive agents in the treatment of hypertension and myocardial ischemia.