70038-38-9Relevant articles and documents
Design and synthesis of new vancomycin derivatives
Gu, Wen,Chen, Bei,Ge, Min
, p. 2305 - 2308 (2014/05/20)
A set of vancomycin derivatives with lipid chain attached via a glyceric acid linker was designed and synthesized. A concise synthesis towards these derivatives was developed and the IC50s of these new lipoglycopeptides were tested. Some of them showed very potent activity against both vancomycin sensitive and resistant strains.
TRANSITION-METAL-CATALYZED REACTIONS OF DIAZOCOMPOUNDS, EFFICIENT SYNTHESIS OF FUNCTIONALIZED ETHERS BY CARBENE INSERTION INTO THE HYDROXYLIC BOND OF ALCOHOLS
Noels, A. F.,Demonceau, A.,Petiniot, N.,Hubert, A. J.,Teyssie, Ph.
, p. 2733 - 2739 (2007/10/02)
An efficient catalytic synthesis of unsaturated ethers by carbene insertion (with diazoesters as carbene precursors) into the OH bond of unsaturated alcohols is reported.The regioselectivity for the OH insertion is high.However, depending on the catalyst counter-ions and the diazoester alkoxy group, addition to the unsaturated centre can be promoted to some extent, yielding then cyclopropyl and cyclopropenyl carbinols.The mechanistic aspects of the reactions are discussed.
Antifungal properties of n-alkoxyacetic acids and their methyl esters
Gershon,Shanks,DeAngelis
, p. 82 - 84 (2007/10/12)
Eleven n-alkoxyacetic acids and their methyl esters, in which the alkyl group was C1-C9, C11, or C13, were tested against Aspergillus niger, Trichoderma viride, and Myrothecium verrucaria in Sabouraud dextrose agar at pH 4.0 and 5.6. Toxicity to Candida albicans, Trichophyton mentagrophytes, and Mucor mucedo was determined in the same medium at pH 5.6 and 7.0 in the absence and presence of 10% beef serum. The fungitoxicity of the acids was influenced by chain length, pH of the medium, and absence or presence of adsorbents. The toxicity of the esters was influenced primarily by chain length and to a lesser extent by the medium pH and the presence of beef serum. The order of activity of the n-alkoxyacetic acids was according to the number of linear atoms in the chain: 11>12>10>9>8>7>6>14>16. T. mentagrophytes was the organism most strongly affected by these compounds, with the esters being slightly more active than the acids. Compared to other fatty acid analogs, the order of fungitoxicity, on a weight basis, was 2-alkynoic acids >2-alkenoic acids > alkanoic acids > 2-bromoalkanoic acid > 2-fluoroalkanoic acids > n-alkoxyacetic acids.
