700844-18-4

Basic information

• Product Name: 4-CHLORO-2-IODOTHIENO[2,3-B]PYRIDINE-5-CARBONITRILE
• Synonyms: 4-CHLORO-2-IODOTHIENO[2,3-B]PYRIDINE-5-CARBONITRILE
• CAS NO: 700844-18-4
• Molecular Formula: C₈H₂ClIN₂S
• Molecular Weight: 320.53735
• Mol File: 700844-18-4.mol

Chemical Properties

• Boiling Point: 429.985 °C at 760 mmHg
• Flash Point: 213.848 °C
• Appearance: /
• Density: 2.166 g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-CHLORO-2-IODOTHIENO[2,3-B]PYRIDINE-5-CARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-2-IODOTHIENO[2,3-B]PYRIDINE-5-CARBONITRILE(700844-18-4)
• EPA Substance Registry System: 4-CHLORO-2-IODOTHIENO[2,3-B]PYRIDINE-5-CARBONITRILE(700844-18-4)

Safety Data

• Hazardous Substances Data: 700844-18-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
4-CHLORO-2-IODOTHIENO[2,3-B]PYRIDINE-5-CARBONITRILE is used as an intermediate in the synthesis of pharmaceuticals for its unique structural features that can be further modified to create new drug molecules.
Used in Agrochemical Synthesis:
In the agrochemical industry, 4-CHLORO-2-IODOTHIENO[2,3-B]PYRIDINE-5-CARBONITRILE is used as a precursor in the development of new agrochemicals, potentially leading to more effective and targeted pest control solutions.
Used in Organic Chemistry as a Building Block:
4-CHLORO-2-IODOTHIENO[2,3-B]PYRIDINE-5-CARBONITRILE is utilized as a building block in organic chemistry, allowing chemists to explore its reactivity and potential for creating novel compounds with various applications.

Upstream product

• 63873-61-0 4-chloro-5-cyanothieno<2,3-b>pyridine 
• 1014692-78-4 C₈H₃IN₂OS 
• 700844-19-5 4-chlorothieno[3,2-b]pyridine-5-carboxylic acid 
• 700844-20-8 4-chlorothieno[3,2-b]pyridine-5-carboxamide 
• 59713-58-5 ethyl 4-chlorothieno<2,3-b>pyridine-5-carboxylate 
• 1014692-78-4 4-hydroxy-2-iodothieno[2,3-b]pyridine-5-carbonitrile 

Downstream Products

• 700844-39-9 4-[(2,4-dichloro-5-methoxyphenyl)amino]-2-iodothieno[3,2-b]pyridine-5-carbonitrile 
• 930292-97-0 4-chloro-2-phenylthieno[2,3-b]pyridine-5-carbonitrile 
• 700844-59-3 4-[(2,4-dichloro-5-methoxyphenyl)amino]-2-(4-formylphenyl)thieno[3,2-b]pyridine-5-carbonitrile 

Relevant articles and documents

Process for the preparation of 4-hydroxythieno[2,3-b]pyridine-5-carbonitriles

A process for the preparation of 4-hydroxythieno[2,3-b]pyridine-5-carbonitriles, which can be useful for the preparation of protein kinase inhibitors, is provided.

A facile, scalable preparation of 4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carbonitriles

We report a new synthesis of thieno[2,3-b]pyridine-5-carbonitriles from 2-aminothiophene-3-carboxylate esters. The key step of the synthesis is a thermally promoted elimination/decarboxylation followed by nucleophilic cyclization to give 4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carbonitriles. The reactions proceed in good yield and generally require no chromatographic purification. These compounds are easily transformed in two steps to 4-chloro-2-iodothieno[2,3-b]pyridine-5-carbonitriles which are key intermediates in the synthesis of various kinase inhibitors.

Identification of 7-phenylaminothieno-[3,2-b]pyridine-6-carbonitriles as a new class of Src kinase inhibitors

We disclose here a new class of kinase inhibitors, obtained by replacing the phenyl ring of a 3-quinolinecarbonitrile system with a thiophene ring. When suitably substituted, the resultant 7-phenylaminothieno[3,2-b]pyridine-6- carbonitrile analogues show

Thieno[3,2-b]pyridine-6-carbonitriles and thieno[2,3-b]pyridine-5-carbonitriles as protein kinase inhibitors

This invention provides compounds of Formula (1a)-(1f), II wherein: X, m, n, q, R1, R2, R3, R4, R5, R6, R7, R8, R9, Y, Q, Z, Z′, Z′″, Z″ and J are defined hereinbefore in the specification, which are useful in the treatment of cancer, stroke, myocardial infarction, neuropathic pain, osteoporosis, polycystic kidney disease, autoimmune disease, rheumatoid arthritis, and transplant rejection and process for producing said compounds.

THIENO[3,2-b]PYRIDINE-6-CARBONITRILES AND THIENO[2,3-b]PYRIDINE-5-CARBONITRILES AS PROTEIN KINASE INHIBITORS

This invention provides compounds of Formula (1 a) - (1f) wherein:X, R1, and R2 are defined hereinbefore in the specification, which are useful in the treatment of cancer, stroke, osteoporosis, polycystic kidney disease, autoimmune disease, rheumatoid arthritis, and transplant rejection and process for producing said compounds.