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D-1-N-BOC-PROLINAMIDE, also known as (S)-N-BOC-1-pyrrolidinecarboxamide, is a chemical compound that is a derivative of proline, a non-essential amino acid. It is widely used in the field of organic chemistry and plays a significant role in the synthesis of various natural and unnatural peptides, peptidomimetics, and biologically active compounds. Its structural resemblance to proline and its use as a chiral auxiliary in asymmetric synthesis make it a valuable component in medicinal chemistry and drug discovery.

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  • 70138-72-6 Structure
  • Basic information

    1. Product Name: D-1-N-BOC-PROLINAMIDE
    2. Synonyms: 1-Pyrrolidinecarboxylic acid, 2-(aminocarbonyl)-, 1,1-dimethylethyl ester, (2R)-;(R)-2-CARBAMOYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;1-BOC-D-PROLINAMIDE;D-N-BOC-PROLINAMIDE;N-ALPHA-BOC-D-PROLINEAMIDE;(2R)-2-carbamoyl-pyrrolidine-1-carboxylic acid tert-butyl ester;(Tert-Butoxy)Carbonyl D-Pro-NH2
    3. CAS NO:70138-72-6
    4. Molecular Formula: C10H18N2O3
    5. Molecular Weight: 214.26
    6. EINECS: N/A
    7. Product Categories: Pyrrole&Pyrrolidine&Pyrroline
    8. Mol File: 70138-72-6.mol
  • Chemical Properties

    1. Melting Point: 100-102 °C
    2. Boiling Point: 370.1 °C at 760 mmHg
    3. Flash Point: 177.6 °C
    4. Appearance: /
    5. Density: 1.155 g/cm3
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C
    8. Solubility: N/A
    9. PKA: 15.97±0.20(Predicted)
    10. CAS DataBase Reference: D-1-N-BOC-PROLINAMIDE(CAS DataBase Reference)
    11. NIST Chemistry Reference: D-1-N-BOC-PROLINAMIDE(70138-72-6)
    12. EPA Substance Registry System: D-1-N-BOC-PROLINAMIDE(70138-72-6)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 70138-72-6(Hazardous Substances Data)

70138-72-6 Usage

Uses

Used in Organic Chemistry:
D-1-N-BOC-PROLINAMIDE is used as a building block for the synthesis of various natural and unnatural peptides and peptidomimetics due to its structural resemblance to proline. This allows for the creation of diverse molecules with potential applications in various fields.
Used as a Chiral Auxiliary in Asymmetric Synthesis:
D-1-N-BOC-PROLINAMIDE is utilized as a chiral auxiliary in asymmetric synthesis, which is crucial for the production of enantiomerically pure compounds. This is important in the development of pharmaceuticals, as the stereochemistry of a molecule can significantly impact its biological activity and efficacy.
Used in the Formation of Biologically Active Compounds:
D-1-N-BOC-PROLINAMIDE serves as a precursory reagent in the formation of various biologically active compounds. Its use in the synthesis of these compounds contributes to the development of new drugs and therapeutic agents with potential applications in medicine and healthcare.

Check Digit Verification of cas no

The CAS Registry Mumber 70138-72-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,0,1,3 and 8 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 70138-72:
(7*7)+(6*0)+(5*1)+(4*3)+(3*8)+(2*7)+(1*2)=106
106 % 10 = 6
So 70138-72-6 is a valid CAS Registry Number.

70138-72-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name Boc-D-Proline amide

1.2 Other means of identification

Product number -
Other names D-1-N-BOC-PROLINAMIDE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:70138-72-6 SDS

70138-72-6Relevant articles and documents

Direct catalytic formation of primary and tertiary amides from non-activated carboxylic acids, employing carbamates as amine source

Tinnis, Fredrik,Lundberg, Helena,Adolfsson, Hans

supporting information, p. 2531 - 2536 (2012/11/06)

The operationally simple titanium(IV)- or zirconium(IV)-catalyzed direct amidation of non-activated carboxylic acids with ammonium carbamates generates primary, and tertiary N,N-dimethyl-substituted amides in good to excellent yields. Copyright

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