70406-92-7

Basic information

• Product Name: Ethyl N-(2,3-dichloro-6-aminobenzyl)glcycine
• Synonyms: Ethyl-N-(2,3-dichloro-6-aminobenzyl)glcycine;N-(6-Amino-2,3-dichlorobenzyl)glycineethylester;Ethyl 2-(6-Amino-2,3-dichlorobenzyl)glycine (Anagrelide Impurity A);Ethyl 2-(6-Amino-2,3-dichlorobenzyl)glycine;ethyl 2-((6-amino-2,3-dichlorobenzyl)amino)acetate;Anagrelide Intermediate
• CAS NO: 70406-92-7
• Molecular Formula: C₁₁H₁₄Cl₂N₂O₂
• Molecular Weight: 277.15
• EINECS: 1592732-453-0
• Product Categories: Amines;Bases & Related Reagents;Impurities;Intermediates & Fine Chemicals;Nucleotides;Pharmaceuticals
• Mol File: 70406-92-7.mol

Chemical Properties

• Boiling Point: 402.412 °C at 760 mmHg
• Flash Point: 197.172 °C
• Appearance: /
• Density: 1.318 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.571
• Storage Temp.: 2-8°C(protect from light)
• PKA: 5.45±0.20(Predicted)
• CAS DataBase Reference: Ethyl N-(2,3-dichloro-6-aminobenzyl)glcycine(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl N-(2,3-dichloro-6-aminobenzyl)glcycine(70406-92-7)
• EPA Substance Registry System: Ethyl N-(2,3-dichloro-6-aminobenzyl)glcycine(70406-92-7)

Safety Data

• Hazardous Substances Data: 70406-92-7(Hazardous Substances Data)

Usage

Uses

Anagrelide impurity A.

InChI:InChI=1/C11H14Cl2N2O2/c1-2-17-10(16)6-15-5-7-9(14)4-3-8(12)11(7)13/h3-4,15H,2,5-6,14H2,1H3

Upstream product

• 105-36-2 ethyl bromoacetate 
• 70380-51-7 3,4-dichloro-2-hydroxymethylaniline 
• 623-33-6 glycine ethyl ester hydrochloride 
• 70380-50-6 N-(2,3-dichloro-6-nitrobenzyl)glycine ethyl ester hydrochloride 
• 1677-47-0 4,5-Dichloro-1H-indole-2,3-dione 

Downstream Products

• 146374-56-3 ethyl (2-cyanoimino-5,6-dichloro-1,2,3,4-tetrahydroquinazolin-3-yl)-acetate 
• 4455-13-4 methylthioacetic acid ethyl ester 
• 200571-11-5 2-cyanoimino-5,6-dichloro-1,2,3,4-tetrahydroquinazoline 
• 146374-56-3 ethyl-(2-cyanoimino-5,6-dichloro-1,2,3,4-tetrahydroquinazolin-3-yl) acetate 
• 58579-51-4 anagrelide hydrochloride 
• 70381-75-8 ethyl-5,6-dichloro-3,4-dihydro-2-(1H)-iminoquinazoline-3-acetate hydrobromide 
• 68475-42-3 anagrelide 

Relevant articles and documents

Process for the Manufacture of Anagrelide Hydrochloride Monohydrate

The present invention relates to a process for preparation of Anagrelide Hydrochloride Monohydrate.

PROCESS FOR THE PREPARATION OF ETHYL-N-(2, 3-DICHLORO-6-NITROBENZYL) GLYCINE HYDROCHLORIDE

The invention relates to a process for the preparation of anagrelide, and for the preparation of intermediates for use in preparing anagrelide. The invention also relates to the inte?nediates per se, in particular compounds of formula (V) where R constitutes a suitable leaving group, which may not be hydrogen. The R group may be is selected from: (i) -SiR1 3, (ii) -CH2Ar, (iii) -COOR2, and (iv) sulfonates such as -SO2R3.

Alkyl 5,6-dichloro-3,4-dihydro-2(1H)-iminoquinazoline-3-acetate hydrohalides

The known blood platelet antiaggregative agent 6,7-dichloro-1,5-dihydroimidazo[2,1-b]quinazolin-2(3H)-one is prepared in high yield via an improved process involving a novel intermediate of the Formula STR1 in which R1 is (lower)alkyl and X is bromo, chloro or iodo. Two processes for the preparation of compounds of the Formula III are disclosed, one of which involves the novel intermediate STR2