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Quino[2,3:3,4]pyrrolo[2,1-b]quinazolin-11(13H)-one, 7-methoxy- is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 704912-40-3 Structure
  • Basic information

    1. Product Name: Quino[2,3:3,4]pyrrolo[2,1-b]quinazolin-11(13H)-one, 7-methoxy-
    2. Synonyms: Quino[2,3:3,4]pyrrolo[2,1-b]quinazolin-11(13H)-one, 7-methoxy-
    3. CAS NO:704912-40-3
    4. Molecular Formula: C19H13N3O2
    5. Molecular Weight: 315.32542
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 704912-40-3.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: Quino[2,3:3,4]pyrrolo[2,1-b]quinazolin-11(13H)-one, 7-methoxy-(CAS DataBase Reference)
    10. NIST Chemistry Reference: Quino[2,3:3,4]pyrrolo[2,1-b]quinazolin-11(13H)-one, 7-methoxy-(704912-40-3)
    11. EPA Substance Registry System: Quino[2,3:3,4]pyrrolo[2,1-b]quinazolin-11(13H)-one, 7-methoxy-(704912-40-3)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 704912-40-3(Hazardous Substances Data)

704912-40-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 704912-40-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,0,4,9,1 and 2 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 704912-40:
(8*7)+(7*0)+(6*4)+(5*9)+(4*1)+(3*2)+(2*4)+(1*0)=143
143 % 10 = 3
So 704912-40-3 is a valid CAS Registry Number.

704912-40-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 7-Methoxy-12H-5,6,11a-triaza-dibenzo[b,h]fluoren-11-one

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:704912-40-3 SDS

704912-40-3Downstream Products

704912-40-3Relevant articles and documents

Synthesis and cytotoxic activity of substituted Luotonin A derivatives

Dallavalle, Sabrina,Merlini, Lucio,Beretta, Giovanni Luca,Tinelli, Stella,Zunino, Franco

, p. 5757 - 5761 (2004)

Luotonin A is a cytotoxic alkaloid that has been shown to inhibit topoisomerase I via stabilization of the binary complex topoisomerase-DNA in the same fashion as camptothecin. The synthesis and the cytotoxic activity on the lung carcinoma cell line H460

Synthesis and topoisomerase I inhibitory properties of luotonin A analogues

Cagir, Ali,Eisenhauer, Brian M.,Gao, Rong,Thomas, Shannon J.,Hecht, Sidney M.

, p. 6287 - 6299 (2004)

Luotonin A, a naturally occurring pyrroloquinazolinoquinoline alkaloid, has been previously demonstrated to be a topoisomerase I poison. A number of luotonin A derivatives have now been prepared through the condensation of anthranilic acid derivatives and 1,2-dihydropyrrolo[3,4-b]quinoline-3-one in the presence of phosphorus oxychloride. When dichloromethane was used as solvent the reaction proceeded to a single product. In contrast when the reaction was carried out in tetrahydrofuran or in phosphorus oxychloride, an additional isomeric product was obtained. The luotonin A analogues were evaluated for their ability to effect stabilization of the covalent binary complex formed between human topoisomerase I and DNA, and for cytotoxicity toward a yeast strain expressing the human topoisomerase I.

Synthesis and topoisomerase poisoning activity of A-ring and E-ring substituted luotonin A derivatives

Nacro, Kassoum,Zha, Conxiang (Charles),Guzzo, Peter R.,Jason Herr,Peace, Denise,Friedrich, Thomas D.

, p. 4237 - 4246 (2007)

A series of A-ring and E-ring analogues of the natural product luotonin A, a known topoisomerase I poison, was evaluated for growth inhibition in human carcinoma and leukemia cell lines. Rational design of structures was based on analogues of the related alkaloid camptothecin, which has been demonstrated to exert cytotoxic effects by the same mechanism of action. When compared to luotonin A, several compounds exhibited an improved topoisomerase I-dependent growth inhibition of a human leukemia cell line.

Concise approach to mono- And disubstituted luotonin A analogs and their cytotoxicity test

Kagawa, Natsuko,Nishimura, Kimiko,Abe, Shinya,Masuko, Takashi,Toyota, Masahiro

, p. 514 - 522 (2019/07/31)

A concise approach for the preparation of luotonin A analogs has been developed. The new synthetic route contains an anion-assisted intramolecular double hetero Diels Alder reaction and a direct oxidative cross coupling reaction. Some synthetic luotonin A analogs show cytotoxic activities against Daudi and Jurkat human cancer cells as potent as camptothecin.

Synthesis and biochemical properties of E-ring modified luotonin a derivatives

Cagir, Ali,Jones, Shannon H.,Eisenhauer, Brian M.,Gao, Rong,Hecht, Sidney M.

, p. 2051 - 2054 (2007/10/03)

Luotonin A is a cytotoxic pyrroloquinazolinoquinoline alkaloid that has been shown to stabilize the human topoisomerase I-DNA covalent binary complex in the same fashion as the antitumor alkaloid camptothecin. A study of the structural elements in luotoni

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