- Efficient synthesis and Suzuki cross-coupling reactions of meso-tetrakis(2,6-dimethyl-4-triflyloxyphenyl)porphyrin
-
An ortho-dimethyl substituted meso-tetrakisarylporphyrin prefunctionalized with triflate groups was prepared in good yield from an accessible 2,6-dimethyl-4-(triflyloxy)benzaldehyde. This porphyrin is an interesting building block, which could directly be
- Taesch, Julien,Dang, Tung T.,Heitz, Valérie
-
-
Read Online
- Preparation of BODIPY probes for multicolor fluorescence imaging studies of membrane dynamics
-
Three different colored fluorescent fatty acids containing BODIPY with extremely high fluorescence quantum yields have been synthesized as probes for investigating the dynamics of membranes. Colored vesicles containing each probe, which were located in th
- Yamada,Toyota,Takakura,Ishimaru,Sugawara
-
-
Read Online
- Synthesis of γ-labeled nucleoside 5′-triphosphates using click chemistry
-
Real-time enzymatic studies are gaining importance as their chemical and technical instrumentation improves. Here we report the efficient synthesis of γ-alkyne modified triphosphate amidates that are converted into a variety of γ-fluorophore labeled triph
- Serdjukow,Kink,Steigenberger,Tomas-Gamasa,Carell
-
-
Read Online
- Direct formylation of fluorine-containing aromatics with dichloromethyl alkyl ethers
-
Formylations of fluorine-containing aromatic compounds with dichloromethyl alkyl ethers have been investigated. Dichloromethyl propyl ether and dichloromethyl butyl ether have been applied for the formylation of fluorine-containing anisoles to give the corresponding aldehydes in good yields. Application of these ethers is preferable to that of methyl ether, which is prepared from volatile methyl formate. Reaction of fluorine-containing phenols with these dichloromethyl alkyl ethers did not give salicylaldehyde derivatives, leading instead to corresponding aryl formates in high yields. A plausible mechanism is discussed.
- Warashina, Takuya,Matsuura, Daisuke,Kimura, Yoshikazu
-
p. 587 - 593
(2019/07/22)
-
- New Acyloxymethyl Ketones: Useful Probes for Cysteine Protease Profiling
-
Peptidyl-acyloxymethyl ketones (AOMKs) belong to a class of selective, irreversible inhibitors (activity-based probes) widely used as chemical tools of investigating proteins, for example, in activity-based protein profiling. The synthesis of the AOMKs has always been challenging and current methodologies involve both solution and solid-phase synthesis. Herein, the synthesis of a new scaffold useful for the preparation of peptidyl-AOMKs is reported and it is demonstrated that the new synthetic probes bearing a 4-functionalized 2,6-dimethylbenzoate efficiently inhibit cysteine proteases like cathepsin B.
- Coman, Anca G.,Paraschivescu, Codruta C.,Hadade, Niculina D.,Juncu, Andrei,Vlaicu, Ovidiu,Popescu, Costin-Ioan,Matache, Mihaela
-
p. 3917 - 3923
(2016/11/11)
-
- Formylation of electron-rich aromatic rings mediated by dichloromethyl methyl ether and TiCl4: Scope and limitations
-
Here the aromatic formylation mediated by TiCl4 and dichloromethyl methyl ether previously described by our group has been explored for a wide range of aromatic rings, including phenols, methoxy- and methylbenzenes, as an excellent way to produce aromatic aldehydes. Here we determine that the regioselectivity of this process is highly promoted by the coordination between the atoms present in the aromatic moiety and those in the metal core.
- Ramos-Tomillero, Iván,Paradís-Bas, Marta,De Pinho Ribeiro Moreira, Ibério,Bofill, Josep María,Nicolás, Ernesto,Albericio, Fernando
-
supporting information
p. 5409 - 5422
(2015/05/13)
-
- A direct and mild formylation method for substituted benzenes utilizing dichloromethyl methyl ether-silver trifluoromethanesulfonate
-
A silver trifluoromethanesulfonate (AgOTf)-promoted direct and mild formylation of benzenes has been developed. The reaction utilizing dichloromethyl methyl ether (Cl2CHOMe) and AgOTf powerfully formylated various substituted benzenes under temperature conditions as low as -78 C without losing the protecting groups on the phenolic hydroxyl group.
- Ohsawa, Kosuke,Yoshida, Masahito,Doi, Takayuki
-
p. 3438 - 3444
(2013/06/26)
-
- Compounds useful as neuro-protective agents
-
This invention relates to novel phenyl oxazoles, thiazoles, oxazolines, oxadiazoles and benzoxazoles useful as neuro-protective agents.
- -
-
-
- Method for treating pain
-
The present invention provides a method for treating pain using a composition comprising certain phenyl oxazoles or phenyl thiazoles in combination with a Drug Useful in the Treatment of Pain.
- -
-
-
- Method for treating neuropathic pain
-
The present invention provides a method for treating neuropathic pain comprising administering an analgesic dosage of a compound of formula I to an animal in need of such treatment certain phenyl oxazoles or phenyl thiazoles.
- -
-
-
- Use of phenyl oxazole or phenyl thiazole derivatives for treating neuropathic pain
-
The present invention provides a method for treating neuropathic pain comprising administering an analgesic dosage of a compound of formula I to an animal in need of such treatment certain phenyl oxazoles or phenyl thiazoles.
- -
-
-
- Use of phenyl oxazole or phenyl thiazole derivatives for treating pain
-
The present invention provides a method for treating pain comprising administering to an animal in need of such treatment, an analgesic dosage of certain phenyl oxazoles or phenyl thiazoles.
- -
-
-
- Method for treating pain
-
The present invention provides a method for treating pain using a composition comprising certain phenyl oxazoles or phenyl thiazoles in combination with a Drug Useful in the Treatment of Pain.
- -
-
-
- Ring-chain tautomerism, oxidation, and NO-reaction of a sterically hindered 1,3-dihydroxyimidazolidine
-
The bis-hydroxylamine 1 does not react with the hindered benzaldehyde 2 in ethanolic solution, in DMSO or DMF even at high temperatures. Reaction only takes place after melting the components without any solvent at about 150°C. The product shows ring-chai
- Weber,Grzesiok
-
p. 823 - 827
(2007/10/03)
-
- Spirocyclic Sesquiterpene Synthesis via Quinone Methide Coupling Reactions. Anhydro-β-rotunol
-
A seven-step total synthesis of 1 is reported, starting with 3,5-dimethylphenol.Formylation with Zn(CN)2 gives 9.Mesylation of the derived alcohol 10 occurs only on the phenolic OH, to give 12.Coupling of this with the dilithium salt 15 of 2,3-dimethylbut
- Marx, John N.,Bih, Qoang-Rung
-
p. 336 - 338
(2007/10/02)
-