- PURINE DERIVATIVES USEFUL AS PI3 KINASE INHIBITORS
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This invention provides a compound which is a purine of formula (Ia) or (Ib): and the pharmaceutically acceptable salts thereof that are inhibitors of PI3K and a selective for the p110δ isoform, which is a class Ia PI3 kinase, over other class Ia PI3 kinases and over class Ib kinases. The compounds may be used to treat diseases and disorders arisi from abnormal cell growth, function or behaviour associated with PI3 kinase such as cance immune disorders, cardiovascular disease, viral infection, inflammation, metabolism/endocrine function disorders and neurological disorders.
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Page/Page column 101
(2009/05/28)
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- CHIRAL CIS-IMIDAZOLINES
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There are provided compounds of Formula (I), or the pharmaceutically acceptable salts thereof, wherein X, Y, Z, V1, V2, R1, R2, R3, R4 and R5 are as herein described, processes for obtaining said compounds and pharmaceutical preparations containing them. These compounds are useful as anticancer agents, in particular as agents in the treatment of solid tumors.
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Page/Page column 140
(2009/05/30)
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- 1-PIPERIDINOPHTHALAZINES AS CARDIAC STIMULANTS
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A series of 1-piperidinophthalazine derivatives as phosphodiesterase inhibitors and cardiac stimulants
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