70775-75-6

Basic information

• Product Name: N,N'-(decane-1,10-diyldi-1(4H)-pyridyl-4-ylidene)bis(octylammonium) dichloride
• Synonyms: N,N'-(decane-1,10-diyldi-1(4H)-pyridyl-4-ylidene)bis(octylammonium) dichloride;Octenidine hydrochloride;OCTENIDINE DIHYDROCHLORIDE;N,N'-(1,10-Decanediyldi-1(4H)-pyridinyl-4-ylidene)bis(1-octanamine) dihydrochloride;N,N'-(1,10-Decanediyldi-1(4H)-pyridinyl-4-ylidene)bis-1-octanaMine Hydrochloride;N'-(decane-1,10-diyldi-1(4H)-pyridyl-4-ylidene)bis(octylaMMoniuM) dichloride;ocenidine dihydrochloride;1-OctanaMine,N,N'-(1,10-decanediyldi-1(4H)-pyridinyl-4-ylidene)bis-, hydrochloride (1:2)
• CAS NO: 70775-75-6
• Molecular Formula: C₃₆H₆₂N₄*2ClH
• Molecular Weight: 623.82616
• EINECS: 274-861-8
• Product Categories: Amines;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 70775-75-6.mol

Chemical Properties

• Melting Point: 215-217℃
• Boiling Point: 609.3 °C at 760 mmHg
• Flash Point: 322.3 °C
• Appearance: /
• Density: 1.046[at 20℃]
• Vapor Pressure: 0Pa at 25℃
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: Soluble in dimethyl sulfoxide and methanol.
• Water Solubility: 14.2g/L at 20℃
• Stability: Hygroscopic
• Merck: 14,6754
• CAS DataBase Reference: N,N'-(decane-1,10-diyldi-1(4H)-pyridyl-4-ylidene)bis(octylammonium) dichloride(CAS DataBase Reference)
• NIST Chemistry Reference: N,N'-(decane-1,10-diyldi-1(4H)-pyridyl-4-ylidene)bis(octylammonium) dichloride(70775-75-6)
• EPA Substance Registry System: N,N'-(decane-1,10-diyldi-1(4H)-pyridyl-4-ylidene)bis(octylammonium) dichloride(70775-75-6)

Safety Data

• Hazardous Substances Data: 70775-75-6(Hazardous Substances Data)

Usage

Uses

Used in Medical Applications:
N,N'-(decane-1,10-diyldi-1(4H)-pyridyl-4-ylidene)bis(octylammonium) dichloride is used as an antiseptic for skin, mucous membranes, and wounds. Its cationic surfactant properties allow it to effectively eliminate harmful microorganisms and reduce the risk of infection.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, N,N'-(decane-1,10-diyldi-1(4H)-pyridyl-4-ylidene)bis(octylammonium) dichloride is utilized for its antiseptic properties, making it a valuable component in the development of various medical products and treatments. Its ability to combat harmful microorganisms contributes to the overall effectiveness and safety of these products.

Flammability and Explosibility

Notclassified

Synthetic route

1,10-bis-(4-chloropyridin-1 (4H)-yl)decane + n-octylamine hydrochloride (142-95-0) → octenidine dihydrochloride (70775-75-6)

Conditions	Yield
In N,N-dimethyl-formamide at 160℃; Inert atmosphere;	94.2%

1,10-dichlorodecane (2162-98-3) + 4-(octylamino)pyridine (64690-19-3) → octenidine dihydrochloride (70775-75-6)

Conditions	Yield
In acetic acid butyl ester for 12h; Reflux;	85.1%
In N,N-dimethyl-formamide at 120 - 180℃;	39%
In water

4-aminopyridine (504-24-5) → octenidine dihydrochloride (70775-75-6)

Conditions	Yield
Multi-step reaction with 2 steps 1: hydrogen; palladium 10% on activated carbon / ethanol / 80 °C / 2625.26 Torr 2: acetic acid butyl ester / 12 h / Reflux View Scheme

Octanal (124-13-0) → octenidine dihydrochloride (70775-75-6)

Conditions	Yield
Multi-step reaction with 2 steps 1: hydrogen; palladium 10% on activated carbon / ethanol / 80 °C / 2625.26 Torr 2: acetic acid butyl ester / 12 h / Reflux View Scheme

octenidine dihydrochloride (70775-75-6) → N,N'-(1,10 decanediyldi-1[4H]-pyridinyl-4-ylidene)-bis-(1-octanamine)

Conditions	Yield
With sodium hydroxide In water; toluene at 20 - 30℃;	14.5 g

Upstream product

• 2162-98-3 1,10-dichlorodecane 
• 64690-19-3 4-(octylamino)pyridine 
• 142-95-0 n-octylamine hydrochloride 
• 504-24-5 4-aminopyridine 
• 124-13-0 Octanal 

Relevant articles and documents

PROCESS FOR THE SYNTHESIS OF N-ALKYL-4-PYRIDINAMINES

The present invention relates to an improved process for the synthesis of N-alkyl-4-pyridinamines comprising the catalytic hydrogenation of a precursor compound which is carried out in the presence of an acid.

The improved method for preparing octenidine dihydrochloride and the method for preparing a pharmaceutical composition containing the octenidine dihydrochloride

The present invention relates to an improved novel method for preparing octenidine dihydrochloride which has chemical name 1 of 10-bis-[4-(octylamino)-1-pyridinium]-decane dichloride, is represented by chemical formula, C_36H_64Cl_2N_4, and has MW of 623.84 and MP of 215~217anddeg;C. The octenidine dihydrochloride is used widely in hospitals and in the general public as an agent for skin sterilization and disinfection. The method according to the present invention can reduce the preparation cost and decrease impurities generated during the preparation process. In addition, the present invention relates to a novel composite and formulation for use in skin sterilization and disinfection, which comprise octenidine dihydrochloride. When using the sterilizing and disinfecting agent according to the present invention, it is possible to provide a method for preparing a safe sterilizing and disinfecting agent which can prevent skin infection, respiratory infection, and hospital infection that becomes a problem recently in relation to a sterilizing and disinfecting agent used in hospitals.COPYRIGHT KIPO 2017

Process for the preparation of bis(4-amino-1-pyridinium) alkanes

Process for the preparation of bis(4-amino-1-pyridinium)alkanes by reacting difunctionalized alkanes with 4-aminopyridines in water or a mixture of water and organic solvent.