64690-19-3Relevant articles and documents
Effect of 4(2)-Octylaminopyridine Distribution in a Water (HCl)/Chloroform System on the Extraction of Metal Ions from Chloride Solutions
Borshch,Ageeva,Frolova, A. Yu.
, p. 828 - 834 (2019)
Abstract: Distributions of 4(2)-octylaminopyridines (4(2)-OAPs) as extractants in an H2O(HCl)/CHCl3 system were studied by UV and IR spectroscopy and potentiometry. The ionization constant of monoprotonated 4-OAP, the logarithmic distribution constant of 4-OAP and its chloride, and the logarithmic extraction constant of hydrochloric acid were calculated. These values were compared with those for 2-OAP. The isotherm (20 ± 2°C) of HCl extraction with 0.1 M 4-OAP in chloroform is given. The difference in the extraction chemistry of hydrochloric acid with 2- and 4-OAPs and specific application features of these reagents for extraction of metals from chloride solutions are discussed.
Synthesis and biological evaluation of novel cyanuric acid-tethered tris-pyridinium derivatives
Derkach, Yana V.,Detusheva, Elena V.,Egorov, Mikhail P.,Frolov, Nikita A.,Minaeva, Alexandra P.,Vereshchagin, Anatoly N.
, p. 368 - 369 (2021/06/07)
Novel tris(4-alkylaminopyridin-1-ium) trichlorides with alkylcyanuric spacer were synthesized by quaternization of 4-alkylaminopyridines with tris(2-chloroethyl) cyanurate. The obtained compounds were evaluated for microbiological activity against five pathogenic bacterial strains (Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus, Acinobacter baumannii, Pseudomonas aeruginosa). The results indicate the presence of pronounced antibacterial properties in this group of compounds.
Method of synthesizing 4-alkylamino pyridine in mild condition
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Paragraph 0018, (2018/01/17)
The invention discloses a method of synthesizing 4-alkylamino pyridine in a mild condition, and belongs to the technical field of organic synthesis. The method comprises performing a nucleophilic substitution reaction on 4-chloropyridine hydrochloride with alkyl amine in the presence of an inhibitor to prepare the 4-alkylamino pyridine, wherein the reaction temperature is in a range of 30-150 DEG C, the reaction time is in a range of 1-10 hours, the inhibitor is a fluoride salt, and the mass ratio of the inhibitor to the 4-chloropyridine hydrochloride is (0.1-1):1. In order to solve the problem of production safety hidden danger caused by a sharp rise of temperature in such kind of nucleophilic substitution reactions, the method provided by the invention introduces the inhibitor to control the reaction speed. With the addition of the inhibitor, the rise of the reaction temperature is effectively controlled, the reaction temperature and reaction speed are reduced to a controllable range, and thus the method provides possibility for safe production and is suitable for large-scale production. In addition, the synthetic reaction has only one step, the yield can reach 80%, and compared with the products of nucleophilic substitution reactions with no inhibitors, the product purity is increased and can reach 99% or more.
