708983-84-0

Basic information

• Product Name: [1,2,4]Triazolo[4,3-a]quinolin-7-amine,4,5-dihydro-1-methyl-(9CI)
• Synonyms: [1,2,4]Triazolo[4,3-a]quinolin-7-amine,4,5-dihydro-1-methyl-(9CI)
• CAS NO: 708983-84-0
• Molecular Formula: C11H12N4
• Molecular Weight: 200.23978
• Product Categories: CYCLOHEXANE
• Mol File: 708983-84-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: [1,2,4]Triazolo[4,3-a]quinolin-7-amine,4,5-dihydro-1-methyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: [1,2,4]Triazolo[4,3-a]quinolin-7-amine,4,5-dihydro-1-methyl-(9CI)(708983-84-0)
• EPA Substance Registry System: [1,2,4]Triazolo[4,3-a]quinolin-7-amine,4,5-dihydro-1-methyl-(9CI)(708983-84-0)

Safety Data

• Hazardous Substances Data: 708983-84-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
[1,2,4]Triazolo[4,3-a]quinolin-7-amine,4,5-dihydro-1-methyl-(9CI) is used as a compound of interest in pharmaceutical research for its potential applications in the development of new drugs. The presence of a triazolo ring and a quinoline core in its structure may contribute to its pharmacological properties, making it a promising candidate for further study and development in various therapeutic areas.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, [1,2,4]Triazolo[4,3-a]quinolin-7-amine,4,5-dihydro-1-methyl-(9CI) is used as a starting point for the exploration of its mechanisms of action and potential biological activities. Its complex molecular structure, including the triazolo and quinoline components, may provide insights into its interactions with biological targets and its potential as a therapeutic agent.

Upstream product

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Relevant articles and documents

Synthesis and inotropic evaluation of 1-substituted-N-(4,5-dihydro-1-methyl-[1,2,4]triazolo[4,3-a]quinolin-7-yl)piperidine-4-carboxamides

A series of 1-substituted-N-(4,5-dihydro-1-methyl-[1,2,4]triazolo[4,3-a]quinolin-7-yl) piperidine-4-carboxamides has been synthesized and evaluated for positive inotropic activity by measuring left atrium stroke volume in isolated rabbit-heart preparation

Synthesis and positive inotropic activity of N-(4,5-dihydro-[1,2,4]triazolo[4,3-a]quinolin-7-yl)-2-(piperazin-1-yl)ac etamide derivatives

A series of N-(4,5-dihydro-[1,2,4]triazolo[4,3-a]quinolin-7-yl)-2-(piperazin-1-yl)ac etamide derivatives were synthesized and their positive inotropic activity was evaluated by measuring left atrium stroke volume on isolated rabbit heart preparations. Several compounds showed favorable activity compared with the standard drug, milrinone, among which N-(1-benzyl-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinolin-7-yl)-2-(4-benzyl piperazin-1-yl)acetamide 6j was found to be the most potent with the 13.2% increased stroke volume (milrinone 4.7%) at concentration of 3 × 10-5 M in our in vitro study. The chronotropic effects of those compounds having inotropic effects were also evaluated in this work.