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709004-41-1

1H-INDOLE-3-CARBOXYLIC ACID, 1-[(4-BROMOPHENYL)METHYL]-, METHYL ESTER is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1H-INDOLE-3-CARBOXYLIC ACID, 1-[(4-BROMOPHENYL)METHYL]-, METHYL ESTER

    Cas No: 709004-41-1

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  • 709004-41-1 Structure

  • Basic information

    1. Product Name: 1H-INDOLE-3-CARBOXYLIC ACID, 1-[(4-BROMOPHENYL)METHYL]-, METHYL ESTER
    2. Synonyms: 1H-INDOLE-3-CARBOXYLIC ACID, 1-[(4-BROMOPHENYL)METHYL]-, METHYL ESTER
    3. CAS NO:709004-41-1
    4. Molecular Formula: C17H14BrNO2
    5. Molecular Weight: 344.2
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 709004-41-1.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 1H-INDOLE-3-CARBOXYLIC ACID, 1-[(4-BROMOPHENYL)METHYL]-, METHYL ESTER(CAS DataBase Reference)
    10. NIST Chemistry Reference: 1H-INDOLE-3-CARBOXYLIC ACID, 1-[(4-BROMOPHENYL)METHYL]-, METHYL ESTER(709004-41-1)
    11. EPA Substance Registry System: 1H-INDOLE-3-CARBOXYLIC ACID, 1-[(4-BROMOPHENYL)METHYL]-, METHYL ESTER(709004-41-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 709004-41-1(Hazardous Substances Data)

709004-41-1 Usage

Molecular structure

A derivative of 1H-indole-3-carboxylic acid with a methyl ester group and a 4-bromophenyl group attached to the indole ring.

Natural occurrence

Found in certain plants.

Chemical classification

A methyl ester derivative.

Potential pharmacological properties

May have potential applications in medicinal chemistry, pharmaceuticals, and drug development.

Biological activity modulation

The 4-bromophenyl group can potentially alter the compound's interactions with biological targets.

Further research needed

Additional investigation is required to fully understand the compound's pharmacological and therapeutic properties.

Check Digit Verification of cas no

The CAS Registry Mumber 709004-41-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,0,9,0,0 and 4 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 709004-41:
(8*7)+(7*0)+(6*9)+(5*0)+(4*0)+(3*4)+(2*4)+(1*1)=131
131 % 10 = 1
So 709004-41-1 is a valid CAS Registry Number.

709004-41-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name methyl 1-(4-bromobenzyl)-1H-indole-3-carboxylate

1.2 Other means of identification

Product number -
Other names 1H-INDOLE-3-CARBOXYLIC ACID,1-[(4-BROMOPHENYL)METHYL]-,METHYL ESTER

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:709004-41-1 SDS

709004-41-1Downstream Products

709004-41-1Relevant articles and documents

Design, synthesis and preliminary biological evaluation of indole-3-carboxylic acid-based skeleton of Bcl-2/Mcl-1 dual inhibitors

Liu, Tingting,Wan, Yichao,Liu, Renshuai,Ma, Lin,Li, Minyong,Fang, Hao

, p. 1939 - 1948 (2017)

The B-cell lymphoma-2 (Bcl-2) family proteins are attractive targets for cancer therapy. In our previous work, the structure-activity relationship of WL-276 was studied. According to the results, rhodanine derivatives show potent binding affinity for Bcl-2 and Mcl-1 protein and show weaker activity against Bcl-XLprotein. Based on the previous results, a new class of indole-3-carboxylic acid-based derivatives were designed and synthesized as Bcl-2/Mcl-1 dual inhibitors. Among them, compound 17 has a Kivalue of 0.26?μM for Bcl-2 protein and is better than WL-276. Furthermore, it inhibits the myeloid cell leukemia sequence 1 (Mcl-1) protein with a Kivalue of 72?nM. Especially, compound 31 can selectively acting on Bcl-2 and Mcl-1 protein but not Bcl-XLprotein, which has great significance for developing dual inhibitors targeting Bcl-2 and Mcl-1 protein, as well as specific antitumor abilities in cells.

Substituted 3 - indole Bcl - 2 protein inhibitor and preparation method and application

-

Paragraph 0088; 0094; 0097; 0118; 0119, (2018/06/14)

The invention discloses a substituted3-indole Bcl-2 protein inhibitor and a preparation method and an application thereof. The compound has a structure as shown in the general formula I or II. The compound of the invention has a strong inhibitory activity to Bcl-2 protein and can prevent or treat related mammalian diseases caused by abnormal expression of Bcl-2 protein. The invention also relates to a pharmaceutical application of a compound of the compound having the structure as shown in the general formula I or II.

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