1H-INDOLE-3-CARBOXYLIC ACID, 1-[(4-BROMOPHENYL)METHYL]-, METHYL ESTER

Base Information

• Chemical Name: 1H-INDOLE-3-CARBOXYLIC ACID, 1-[(4-BROMOPHENYL)METHYL]-, METHYL ESTER
• CAS No.: 709004-41-1
• Molecular Formula: C17H14BrNO2
• Molecular Weight: 344.208
• Mol file: 709004-41-1.mol

Synonyms:1H-INDOLE-3-CARBOXYLIC ACID,1-[(4-BROMOPHENYL)METHYL]-,METHYL ESTER;

Chemical Property of 1H-INDOLE-3-CARBOXYLIC ACID, 1-[(4-BROMOPHENYL)METHYL]-, METHYL ESTER

Chemical Property:

• PSA: 31.23000
• LogP: 4.23870

Purity/Quality:

98% ^*data from raw suppliers

1H-INDOLE-3-CARBOXYLICACID,1-[(4-BROMOPHENYL)METHYL]-,METHYLESTER 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-INDOLE-3-CARBOXYLIC ACID, 1-[(4-BROMOPHENYL)METHYL]-, METHYL ESTER

There total 1 articles about 1H-INDOLE-3-CARBOXYLIC ACID, 1-[(4-BROMOPHENYL)METHYL]-, METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

3-methoxycarbonylindole (942-24-5) + 1-bromomethyl-4-bromobenzene (589-15-1) → 1-(4-bromobenzyl)-1H-indole-3-carboxylic acid methyl ester (709004-41-1)

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; at 30 ℃;

Reference yield: 100.0%

1-(4-bromobenzyl)-1H-indole-3-carboxylic acid methyl ester (709004-41-1) + 4-Chlorophenylboronic acid (1679-18-1) → 1-((4'-chloro-[1,1'-biphenyl]-4-yl)methyl)-1H-indole-3-carboxylic acid methyl ester

Guidance literature:

With palladium diacetate; sodium carbonate; triphenylphosphine; In dimethyl sulfoxide; at 80 ℃; Inert atmosphere;

DOI:10.1016/j.bmc.2017.02.014

Reference yield: 80.0%

1-(4-bromobenzyl)-1H-indole-3-carboxylic acid methyl ester (709004-41-1) + phenylboronic acid (98-80-6) → methyl 1-([1,1'-biphenyl]-4-ylmethyl)-1H-indole-3-carboxylate

Guidance literature:

With palladium diacetate; sodium carbonate; triphenylphosphine; In dimethyl sulfoxide; at 80 ℃; Inert atmosphere;

DOI:10.1016/j.bmc.2017.02.014

upstream raw materials:

3-methoxycarbonylindole

1-bromomethyl-4-bromobenzene