- Succinylcholine chloride preparation method
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The invention relates to a succinylcholine chloride preparation method, and specifically discloses a synthetic method for preparing succinylcholine chloride by using succinic acid as a starting raw material through a chlorination reaction and an esterification reaction. According to the invention, the method has advantages of safe production, low production cost, high reaction efficiency and simple product purification, and is suitable for mass production of bulk drugs.
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Paragraph 0063-0073
(2020/02/29)
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- Refining method of succinylcholine chloride
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The invention discloses a refining method of succinylcholine chloride. A crude product of succinylcholine chloride is added into a polar aprotic solvent and recrystallized to obtain a refined productof succinylcholine chloride, and related substances of the product meet USP pharmacopoeia standards. The invention provides a refining method of succinylcholine chloride with simple process, convenient operation, low production cost, high product purity, stable process and suitability for industrial production, and also provides a raw material or bulk drug of high-purity succinylcholine chloride.
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Paragraph 0040-0041
(2020/02/14)
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- PROCESS FOR PREPARATION OF SUCCINYLCHOLINE CHLORIDE
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The present invention relates to a process for the preparation of succinylcholine chloride, a pharmaceutically active compound used as skeletal muscle relaxant which comprises condensing succinic anhydride with N,N-diemthylaminoethanol using a catalyst in presence of a solvent to form bis[2-(dimethylamino)ethyl]succinate; in situ purifying the bis[2-(dimethylamino)ethyl]succinate using a base; reacting pure bis[2-(dimethylamino)ethyl]succinate with methyl chloride gas using an alcohol; and purifying the obtained crude succinylcholine chloride using water and alcohol.
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Page/Page column
(2014/04/18)
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- PROCESS FOR PREPARATION OF SUCCINYLCHOLINE CHLORIDE
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The invention discloses a novel process for preparation of succinylcholine chloride via transesterification of succinic acid diester with choline chloride.
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Page/Page column 8
(2014/03/21)
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- Process for the preparation of succinylcholine halides
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Preparation of succinylcholine halides of formula I: STR1 by reacting dialkyl succinates with an excess dimethylaminoethanol in the presence of an alkali metal alcoholate or alkali metal amide catalyst and then reacting the resulting bis(2-dimethylaminoethyl) succinates with methyl halides.
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