71109-34-7

Basic information

• Product Name: 3-METHYL-ISOTHIAZOLO[5,4-B]PYRIDINE
• Synonyms: 3-METHYL-ISOTHIAZOLO[5,4-B]PYRIDINE
• CAS NO: 71109-34-7
• Molecular Formula: C7H6N2S
• Molecular Weight: 150.20094
• Mol File: 71109-34-7.mol

Chemical Properties

• Melting Point: 83.1-84.5 °C
• Boiling Point: 178.723 °C at 760 mmHg
• Flash Point: 60.212 °C
• Appearance: /
• Density: 1.298 g/cm³
• Vapor Pressure: 1.319mmHg at 25°C
• Refractive Index: 1.675
• Storage Temp.: 2-8°C
• PKA: 3.32±0.50(Predicted)
• CAS DataBase Reference: 3-METHYL-ISOTHIAZOLO[5,4-B]PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-METHYL-ISOTHIAZOLO[5,4-B]PYRIDINE(71109-34-7)
• EPA Substance Registry System: 3-METHYL-ISOTHIAZOLO[5,4-B]PYRIDINE(71109-34-7)

Safety Data

• Hazardous Substances Data: 71109-34-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C7H6N2S/c1-5-6-3-2-4-8-7(6)10-9-5/h2-4H,1H3

Upstream product

• 128071-75-0 2-bromopyridine-3-carboxaldehyde 
• 84199-61-1 1-(2′-bromo-3′-pyridyl)ethan-1-one 
• 55676-21-6 3-acetyl-2-chloropyridine 
• 129211-81-0 6-Chloro-3-methylisoxazolo<4,5-c>pyridine-4-thiol 
• 129211-84-3 6-Chloro-3-methylisothiazolo<5,4-b>pyridin-4-ol 
• 129211-83-2 6-Chloro-3-(1-iminoethyl)-2-mercaptopyridin-4-ol 
• 58315-12-1 4,6-dichloro-3-methylisoxazolo<4,5-c>pyridine 
• 129211-88-7 4,6-Dichloro-3-methylisothiazolo<5,4-b>pyridine 
• 24340-76-9 3-methyl-5-aminothiazole 
• 19060-08-3 3-ethoxyacrolein 

Relevant articles and documents

Metal-free visible light-promoted synthesis of isothiazoles: A catalytic approach for N-S bond formation from iminyl radicals under batch and flow conditions

A sustainable synthesis of isothiazoles has been developed using an α-amino-oxy acid auxiliary and applying photoredox catalysis. This simple strategy features mild conditions, broad scope and wide functional group tolerance representing a new enviromenta

Microwave-assisted synthesis of 3-methylisothiazolo[5,4-b]pyridine and various 2-amino derivatives of thieno[2,3-b]pyridine and 1-(2-aminopyridin-3-yl) ethanone

Various 2-amino derivatives of thieno[2,3-b]pyridin-2-amine (3a-g) were prepared in fair to good yields (3076%) by subjecting 1-(2-chloro-pyridin-3-yl) ethanone (1) and appropriate primary amine (2a-g) to microwave heating at 90120 °C for 1520 min in the

Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, pyrazolopyridines, isothiazolopyridines, and preparation and uses thereof

The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nACh receptors), activation of nACh receptors, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain. Further, this invention relates to novel compounds (e.g., indazoles and benzothiazoles), which act as ligands for the α7 nACh receptor subtype, methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.

Synthetic Investigation on Isothiazolo-- and --pyridines

Different approaches to the title ring systems were examined, based on the cleavage of the N-O bond in the isoxazolopyridine-4-thiols (3) and (4) which afforded the hydroxy derivatives (6) and (7), respectively, in moderate to good yields. 3-Methylisothiazolo-- and --pyridine (11) and (18), as well as several functionalized derivatives, were easily obtained from these key intermediates through the corresponding 4,6-dichloroisothiazolopyridines (10) and (17).