- Transfer Hydrogenation of Carbonyl Derivatives Catalyzed by an Inexpensive Phosphine-Free Manganese Precatalyst
-
A very simple and inexpensive catalytic system based on abundant manganese as transition metal and on an inexpensive phosphine-free bidendate ligand, 2-(aminomethyl)pyridine, has been developed for the reduction of a large variety of carbonyl derivatives with 2-propanol as hydrogen donor. Remarkably, the reaction proceeds at room temperature with low catalyst loading (down to 0.1 mol %) and exhibits a good tolerance toward functional groups. High TON (2000) and TOF (3600 h-1) were obtained.
- Bruneau-Voisine, Antoine,Wang, Ding,Dorcet, Vincent,Roisnel, Thierry,Darcel, Christophe,Sortais, Jean-Baptiste
-
supporting information
p. 3656 - 3659
(2017/07/15)
-
- Synthesis, enantiomeric separation and docking studies of spiropiperidine analogues as ligands of the nociceptin/orphanin FQ receptor
-
A series of triazospirodecanone derivatives were synthesized as potential NOP ligands. 8-(Chroman-4-yl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one (4) and its 5-fluoro analogue (18) proved to be active as agonists with EC50 values in the submicromolar range. Single enantiomers of compound 4 were separated and tested as NOP agonists; the eutomer R-(+)-4 showed a pEC 50 of 7.34. Finally docking studies were performed on the NOP receptor to identify the most significant stereospecific interactions.
- Battisti, Umberto M.,Corrado, Sandra,Sorbi, Claudia,Cornia, Andrea,Tait, Annalisa,Malfacini, Davide,Cerlesi, Maria Camilla,Calò, Girolamo,Brasili, Livio
-
p. 973 - 983
(2014/07/08)
-
- Silylation-based kinetic resolution of monofunctional secondary alcohols
-
The nucleophilic small molecule catalyst (-)-tetramisole was found to catalyze the kinetic resolution of monofunctional secondary alcohols via enantioselective silylation. Optimization of this new methodology allows for selectivity factors up to 25 utilizing commercially available reagents and mild reaction conditions.
- Sheppard, Cody I.,Taylor, Jessica L.,Wiskur, Sheryl L.
-
p. 3794 - 3797
(2011/10/02)
-
- 1,2,3,4-Tetrahydropyrazin-2-yl acetamides and methods of use
-
Selected compounds are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and
- -
-
Page/Page column 40
(2010/02/15)
-
- Synthesis and activity of novel and selective Iks-channel blockers
-
Since the discovery of the IKs-potassium channel as the slowly activating component of the delayed rectifier current (Ik) in cardiac tissue, the search for blockers of this current has been intense. During the screening of KATP
- Gerlach,Brendel,Lang,Paulus,Weidmann,Brüggemann,Busch,Suessbrich,Bleich,Greger
-
p. 3831 - 3837
(2007/10/03)
-
- Reverse asymmetric catalytic epoxidation of unfunctionalized alkenes
-
New salen Mn(III) complexes (S,S)-6a-e prepared from tartaric-derived alicyclic C2 symmetric vicinal diamines were studied in the catalysis of the asymmetric epoxidation of unfunctionalized alkenes. Although the enantioselectivities obtained we
- Scheurer, Andreas,Mosset, Paul,Spiegel, Martina,Saalfrank, Rolf W.
-
p. 1063 - 1078
(2007/10/03)
-
- Chromenes and chromanones. Part IV.1 The Birch reduction of 2,2-dimethyl-4-chromanone and its 7-substituted analogues
-
2,2-Dimethyl-4-chromanone (1a), 2,2,7-trimethyl-4-chromanone (1b) and 7-methoxy-2,2-dimethyl-4-chromanone (1c) have been reduced by sodium or lithium in liquid ammonia with the presence or without of proton donor. The bicyclic or phenolic products were obtained. Products with reduced benzene ring only were also observed. The possible mechanisms of reductions are considered.
- Aniol, Miroslaw
-
p. 1069 - 1079
(2007/10/03)
-
- Modification of hydroxybenzopyranoids: Facile deoxygenation of 2,2-dimethyl-7-hydroxy-4-chromanones and a new approach to their novel mercapto analogs
-
A facile deoxygenation of a systematic series of substituted 2,2-dimethyl-7-hydroxy-4-chromanones via their sulfonate, isourea, and thiocarbamate derivatives is reported. The synthesis of novel 2,2-dimethyl-7-mercapto-4-chromanones has been accomplished b
- Sebok,Timar,Eszenyi,Patonay
-
p. 6318 - 6321
(2007/10/02)
-
- Unsaturated N-benzopyranyllactams
-
Compounds I STR1 where R1 is H, alkyl, alkoxy, CO alkyl, COOH, carboxyalkyl, CONR2, CN, NO2, alkylsulfi(o)nyl, arylsulfi(i)-nyl; R2 is H, OH, alkoxy, alkyl or alkylcarbonyl, R3 /R4 are alky
- -
-
-