719274-84-7

Basic information

• Product Name: Bicyclo[2.2.2]octane-1-carbonitrile, 4-[4-Methyl-5-[2-(trifluoroMethyl)phenyl]-4H-1,2,4-triazol-3-yl]-
• Synonyms: Bicyclo[2.2.2]octane-1-carbonitrile, 4-[4-Methyl-5-[2-(trifluoroMethyl)phenyl]-4H-1,2,4-triazol-3-yl]-;4-(4-Methyl-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazol-3-yl)bicyclo[2.2.2]octane-1-carbonitrile
• CAS NO: 719274-84-7
• Molecular Formula: C₁₉H₁₉F₃N₄
• Molecular Weight: 360.3761696
• Mol File: 719274-84-7.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Bicyclo[2.2.2]octane-1-carbonitrile, 4-[4-Methyl-5-[2-(trifluoroMethyl)phenyl]-4H-1,2,4-triazol-3-yl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Bicyclo[2.2.2]octane-1-carbonitrile, 4-[4-Methyl-5-[2-(trifluoroMethyl)phenyl]-4H-1,2,4-triazol-3-yl]-(719274-84-7)
• EPA Substance Registry System: Bicyclo[2.2.2]octane-1-carbonitrile, 4-[4-Methyl-5-[2-(trifluoroMethyl)phenyl]-4H-1,2,4-triazol-3-yl]-(719274-84-7)

Safety Data

• Hazardous Substances Data: 719274-84-7(Hazardous Substances Data)

Upstream product

• 108-77-0 1,3,5-trichloro-2,4,6-triazine 
• 719274-83-6 4-{4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-3-yl}bicyclo[2.2.2]octane-1-carboxamide 
• 719274-90-5 methyl 4-{4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-3-yl}bicyclo[2.2.2]octane-1-carboxylate 
• 935273-84-0 4-{4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-3-yl}bicyclo[2.2.2]octane-1-carboxylic acid 

Downstream Products

• 935273-85-1 N'-hydroxy-4-{4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-3-yl}bicyclo[2.2.2]octane-1-carboximidamide 
• 1206687-12-8 [(4-{4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-3-yl}bicyclo[2.2.2]oct-1-yl)methyl]amine 
• 935273-85-1 C₁₉H₂₂F₃N₅O 

Relevant articles and documents

SEH AND 11β-HSD1 DUAL INHIBITORS

The invention is directed to bicycle[2.2.2]oct-1-yl compounds, pharmaceutical compositions containing them and their use in the treatment of a variety of conditions mediated by the sEH enzyme and/or the 11β-HSD1 enzyme.

Triazole derivatives which are SMO antagonists

The present invention provides a method for the treatment or prevention of conditions which can be ameliorated by Smo antagonism, which method comprises administration to a patient in need thereof of an effective amount of a compound of formula I or a com

TRIAZOLE DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE-1

Triazole derivatives of structural formula I are selective inhibitors of the 11β-hydroxysteroid dehydrogenase-1. The compounds are useful for the treatment of diabetes, such as noninsulin-dependent diabetes (NIDDM), hyperglycemia, obesity, insulin resista

Triazole derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase-1

Triazole derivatives of structural formula I are selective inhibitors of the 11β-hydroxysteroid dehydrogenase-1. The compounds are useful for the treatment of diabetes, such as noninsulin-dependent diabetes (NIDDM), hyperglycemia, obesity, insulin resista