7248-39-7

Basic information

• Product Name: 2-nitro-1-phenylbutan-1-ol
• CAS NO: 7248-39-7
• Molecular Formula: C₁₀H₁₃NO₃
• Molecular Weight: 195.2151
• Mol File: 7248-39-7.mol

Chemical Properties

• Boiling Point: 332.4°C at 760 mmHg
• Flash Point: 143.1°C
• Density: 1.171g/cm³
• Vapor Pressure: 5.84E-05mmHg at 25°C
• Refractive Index: 1.543
• CAS DataBase Reference: 2-nitro-1-phenylbutan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-nitro-1-phenylbutan-1-ol(7248-39-7)
• EPA Substance Registry System: 2-nitro-1-phenylbutan-1-ol(7248-39-7)

Safety Data

• Hazardous Substances Data: 7248-39-7(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 108-03-2 1-Nitropropane 
• 75-09-2 dichloromethane 
• 64-02-8 disodium ethylenediaminetetraacetic acid 

Downstream Products

• 72936-48-2 1-(dimethyl-t-butyl-silyloxy)-2-nitro-1-phenyl-butan 
• 72936-48-2 erythro-1-(t-butyl)dimethylsilyloxy-2-nitro1-phenylbutane 
• 72936-48-2 threo-1-(t-butyl)dimethylsilyloxy-2-nitro1-phenylbutane 
• 5897-76-7 2-Amino-1-phenyl-1-butanol 
• 5897-76-7 (+/-)-(1R,2S)-2-amino-1-phenyl-1-butanol 
• 5897-76-7 threo-2-amino-1-phenyl-1-butanol 
• 172794-57-9 1-acetoxy-2-nitro-1-phenylbutane 
• 72943-00-1 2-Amino-1-phenyl-butan-1-ol; compound with oxalic acid 
• 79880-94-7 1-<1'-(t-butyl)dimethylsilyloxy-1'-phenyl>methyl-propylamine 

Relevant articles and documents

Synthesis of Metallomacrocycle and Coordination Polymers with Pyridine-Based Amidocarboxylate Ligands and Their Catalytic Activities towards the Henry and Knoevenagel Reactions

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A highly diastereo-and enantioselective copper(I)-catalyzed henry reaction using a bis(sulfonamide)-diamine ligand

A series of bis(sulfonamide)-diamine (BSDA) ligands were synthesized from commercially available chiral α-amino alcohols and diamines. The chiral BSDA ligand 3a, coordinated with Cu(I), catalyzes the enantioselective Henry reaction with excellent enantios

Cyclen-catalyzed Henry reaction under neutral conditions

A convenient cyclen-catalyzed Henry reaction of aldehydes with nitroalkanes under mild and neutral conditions is reported. This procedure constitutes the first cyclen-catalyzed synthesis of nitroalcohols and is adapted to the condensation of both aromatic and aliphatic aldehydes with nitromethane in THF at room temperature without addition of stoichiometric amount of the base. A wide range of substrates, β-nitroalcohols, were obtained in moderate to good yields (up to 98%) using this methodology.

Synthesis of new proazaphosphatranes and their application in organic synthesis

We report herein the synthesis of the new proazaphosphatrane strong bases P(RNCH2CH2)3N (R=Me3CCH2, Me2CHCH2) and P(HNCH2CH2)2NCH2CH2 N-i-Pr (1g). The new azaphosphatranes [HP(RNCH2CH2)3N]Cl (R=Me3CCH2, Me2CHCH2) have P-Nax distances of 2.047 and 1.958 ?, respectively. We also report the synthesis of the tetramine precursor proazaphosphatrane 1g [namely, (H2NCH2CH2) 2NCH2CH2NH-i-Pr] in 41% yield and the use of a complexation-extraction technique to separate it from a mixture containing the di- and tri-isopropyl substituted analogs. Using a 31P NMR technique, we report the pKa value for 1gH+ (34.49). The catalytic properties of three bases P(RNCH2CH2)3N (R=i-Pr, Piv, i-Bu) are compared in the synthesis of several β-hydroxy nitriles, β-nitroalkanols, α,β-unsaturated esters and for the Michael addition of allyl alcohol to α,β-unsaturated ketones.

P(RNCH2CH2)3N: An Efficient Promoter for the Nitroaldol (Henry) Reaction

The use of catalytic amounts of the proazaphosphatranes P(MeNCH2CH2)3N, P(i-PrNCH2CH2)3N and P(HNCH2CH2)(i-PrNCH2CH2) 2N as nonionic bases in the reaction of nitroalkanes with carbonyl compounds is reported. The reaction proceeds at room temperature in the presence of 2.2 equiv of magnesium sulfate to produce the corresponding β-nitroalkanols in generally superior yields. Aldehydes react quantitatively in 5-60 min, whereas ketones require up to 3 h to react with nitromethane and up to 7 h for the reaction of ketones with higher nitroalkanes.

Nitroaldol (Henry) reaction catalyzed by amberlyst A-21 as a far superior heterogeneous catalyst

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A CONVENIENT SYNTHESIS OF 2-CYANOPYRROLES FROM ISOCYANOACETONITRILE

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