727726-47-8

Upstream product

• 775-12-2 diphenylsilane 
• 98-88-4 benzoyl chloride 
• 312-40-3 difluorodiphenylsilane 
• 727726-46-7 [(2R)-2-methyl-3-(phenylmethoxy)-1-propyl][1-(benzoylamino)-2-phenylethyl]diphenylsilane 
• 727726-44-5 2-[[1-[(2R)-2-methyl-3-(phenylmethoxy)-1-propyl]diphenylsilyl]-2-phenylethyl]-1H-isoindole-1,3(2H)-dione 
• 727726-31-0 [(2R)-2-methyl-3-(phenylmethoxy)-1-propyl][2-(phenylmethyl)-1,3-dithian-2-yl]diphenylsilane 
• 727726-40-1 [(2R)-2-methyl-3-(phenylmethoxy)-1-propyl][2-phenyl-1-oxoethyl]diphenylsilane 
• 727726-42-3 [(2R)-2-methyl-3-(phenylmethoxy)-1-propyl][2-phenyl-1-hydroxyethyl]diphenylsilane 
• 849773-85-9 [(2R)-2-methyl-3-(phenylmethoxy)-1-propyl][1-amino-2-phenylethyl]diphenylsilane 
• 727726-30-9 [2-(phenylmethyl)-1,3-dithian-2-yl]fluorodiphenylsilane 
• 31593-52-9 2-benzyl-1,3-dithiane 

Downstream Products

• 727726-54-7 (2R)-3-[[(1R)-1-(benzoylamino)-2-phenylethyl]diphenylsilyl]-2-methylpropanoic acid 
• 727726-57-0 (S)-1-{(R)-3-[((R)-1-benzamido-2-phenylethyl)difluoro sily-l]-2-methylpropanoyl}pyrrolidine-2-carboxylic acid 
• 727726-50-3 (2R)-1-[3-[[(1R)-1-(benzoylamino)-2-phenylethyl]diphenylsilyl]-2-methyl-1-oxopropyl]-L-proline 1,1-dimethylethyl ester 

Relevant academic research and scientific papers

An effective total synthesis of four angiotensin-converting enzymes containing silanediols

Four angiotensin-converting enzymes (ACE) containing silanediols 1 have been synthesized successfully in 8% overall yield in 8 steps from inexpensive starting materials such as diphenyldichlorosilane 5, β-methylallylic alcohol 7 and Ellman sulfinimine 9.

Silanediol inhibitors of angiotensin-converting enzyme. Synthesis and evaluation of four diastereomers of Phe[Si]Ala dipeptide analogues

Four stereoisomers of a Phe-Ala silanediol dipeptide mimic have been evaluated as inhibitors of angiotensin-converting enzyme (ACE) and compared to ketone-based inhibitors reported by Almquist et al. One stereogenic center of the isomers was derived from

Silanediol peptidomimetics. Evaluation of four diastereomeric ACE inhibitors

Four diastereomers of a Phe-Ala peptide mimic incorporating a central silanediol group have been individually prepared and tested as inhibitors of angiotensin-converting enzyme (ACE). Three of the silanediols exhibit levels of inhibition that are similar