7340-09-2

Basic information

• Product Name: acetamido acetate
• Synonyms: acetamido acetate;N,O-Diacetylhydroxylamine;N-Acetyloxyacetamide;O2-Acetylacetohydroximic acid
• CAS NO: 7340-09-2
• Molecular Formula: C₄H₇NO₃
• Molecular Weight: 117.1
• Mol File: 7340-09-2.mol

Chemical Properties

• Melting Point: 90 °C
• Appearance: /
• Density: 1.126g/cm³
• Refractive Index: 1.413
• CAS DataBase Reference: acetamido acetate(CAS DataBase Reference)
• NIST Chemistry Reference: acetamido acetate(7340-09-2)
• EPA Substance Registry System: acetamido acetate(7340-09-2)

Safety Data

• Hazardous Substances Data: 7340-09-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C4H7NO3/c1-3(6)5-8-4(2)7/h1-2H3,(H,5,6)

Upstream product

• 75-36-5 acetyl chloride 
• 614-00-6 N-methyl-N-nitrosoaniline 
• 3451-88-5 1,1'-Diacetyl-1,1',4,4'-tetrahydro-4,4'-bipyridine 
• 382165-80-2 N-nitrosodiphenylamine 
• 546-88-3 acetylhydroxamic acid 
• 830-03-5 4-nitrophenol acetate 
• 41879-86-1 acetohydroxamate anion 

Downstream Products

• 546-88-3 acetylhydroxamic acid 
• 64-19-7 acetic acid 
• 87842-89-5 N,O-diacetyl-N-(cyclohexenylmethyl)hydroxylamine 
• 93-26-5 2-methoxyacetanilide 
• 51-66-1 4-methoxyacetanilide 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 103-89-9 4-Methylacetanilide 
• 1012057-93-0 N-acetoxy-N-(6-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)hexyl)acetamide 

Relevant articles and documents

The α-effect in micelles: Nucleophilic substitution reaction of p-nitrophenyl acetate with N-phenylbenzohydroxamate ion

Pseudo-first-order rate constants have been determined for the nucleophilic substitution reactions of p-nitrophenyl acetate with p-chlorophenoxide (4-ClC6H4O-) and N-phenylbenzohydroxamate (C6H5CON(C

Inorganic anionic oxygen-containing α-nucleophiles - Effective acyl group acceptors: Hydroxylamine ranks first among the α-nucleophile series

Comparative analysis of the nucleophilicity of inorganic oxygen-containing α-nucleophiles (hydroxylamine and ClO-, BrO--, HOO--, NH2O-, and F- ions) covering the pKa range from -2 to 13.81 toward 4-nitrophenyl esters (4-nitrophenyl acetate, 4-nitrophenyl p-toluenesulfonate, diethyl 4-nitrophenyl phosphate, ethyl 4-nitrophenyl ethylphosphonate, and 4-nitrophenyl dimethylcarbamate) in water at 25°C (ionic strength μ 1.0, KCl) was performed in terms of the extrathermodynamic Brosted relation. It was found for the first time that hydroxylamine anion ranks first among the series of α-nucleophiles. It is more reactive than HOO- ion with respect to 4-nitrophenyl acetate (by a factor of ～8), 4-nitrophenyl p-toluenesulfonate (by a factor of ～4) and 4-nitrophenyl dimethylcarbamate (by a factor of ～10). The nucleophilicities of HOO- and NH 2O- ions toward diethyl 4-nitrophenyl phosphate and ethyl 4-nitrophenyl ethylphosphonate are comparable. Taking into account that neutral hydroxylamine exhibits an anomalously high reactivity, as compared to not only common organic but also inorganic α-nucleophiles, it may be regarded as a unique α-nucleophile. Both neutral hydroxylamine and its anion as O-nucleophiles ensure high rates of acyl group transfer throughout a wide range of pH.

NAD(P)H and Acetyl-CoA Models: Part II - Reaction of Diphenylnitrosamine and Methylphenylnitrosamine with 1,1'-Diacetyl-1,1',4,4'-tetrahydro-4,4'-bipyridine

Diphenylnitrosamine (1a) and methylphenylnitrosamine (1b) have been treated with 1,1'-diacetyl-1,1',4,4'-tetrahydro-4,4'-bipyridine (DTB) to understand the pattern arising as a result of biomimetic transfer of hydride and acetyl cation from the reagent.A number of products have been isolated and characterized.The interesting feature of the reaction is the -N-N=O cleavage in 1 to give hydroxylamine derivative, O-acetylacetohydroxamic acid (5).