7358-62-5Relevant articles and documents
Method for preparing barbituric acid hydrocarbylation derivative by using ferrous complex
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Paragraph 0042-0046, (2021/07/17)
The invention relates to a method for preparing a barbituric acid hydrocarbylation derivative by using a ferrous complex, which comprises the steps of carrying out coupling reaction at room temperature by using barbituric acid and alcohol as raw materials and the ferrous complex containing an ortho-carboryl benzothiazole structure as a catalyst to prepare the barbituric acid hydrocarbylation derivative. Compared with the prior art, the method has the advantages that the ferrous complex containing the ortho-carboryl benzothiazole structure is applied to catalysis of coupling reaction of barbituric acid and alcohol, the barbituric acid hydrocarbylation derivative is prepared by a one-pot method, the barbituric acid hydrocarbylation derivative is synthesized by using simple, easily available and cheap raw materials at room temperature, and the method has the advantages of low catalyst use equivalent, mild reaction conditions, high substrate universality and high yield.
Mono C-alkylation and mono C-benzylation of barbituric acids through zinc/acid reduction of acyl, benzylidene, and alkylidene barbiturate intermediates
Jursic, Branko S.,Stevens, Edwin D.
, p. 2203 - 2210 (2007/10/03)
Through systematic exploration of reaction conditions, very efficient preparative procedures for obtaining large quantities of substituted 5-alkyl and 5-benzylbarbituric acids were developed. The procedure involves a two step preparation in which the second step is zinc dust/acid reduction. For preparation of 5-alkylbarbiturates, the first step is the preparation of either 5-acyl or 5-alkylidenebarbiturate. If 5-benzylbarbiturate is the target product, then the first step includes the preparation of 5-benzylidene. Regardless of the nature of the first step, all reactions presented synthetic yields around 90% and isolation and purification involves only crystallization.
Reductive C-alkylation of barbituric acid derivatives with carbonyl compounds in the presence of platinum and palladium catalysts
Jursic, Branko S.,Neumann, Donna M.
, p. 4103 - 4107 (2007/10/03)
Effective synthetic procedures for the preparation of mono- and di-C-alkylated barbituric acid derivatives through palladium and platinum catalytic hydrogenation of solutions of barbituric acids (unsubstituted, N-mono, and N,N′-disubstituted barbituric acids) and carbonyl compounds (aliphatic and aromatic aldehydes and ketones).
ALKYLATION OF 1,3-DIMETHYLBARBITURIC ACID BY ALKYL IODIDES
Krasnov, K. A.,Slesarev, V. I.,Artem'eva, Z. L.
, p. 1402 - 1405 (2007/10/02)
The alkylation of 1,3-dimethylbarbituric acid by methyl iodide, ethyl iodide, and isopropyl iodide in the presence of triethylamine was investigated.The kinetics of the process were studied, and it was shown that the steric and electronic factors affect the rate of the alkylation reactions.Only the products from alkylation at the C5 atom are formed in the case of methyl iodide, and concurrent alkylation at the C5 and O4(6) atoms is observed with ethyl iodide and isopropyl iodide.
